Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells
about
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseasesLack of correlation between the levels of soluble cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and the CT-60 genotypesBTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1CTLA-4 interacts with STAT5 and inhibits STAT5-mediated transcription.IFN-gamma-dependent regulatory circuits in immune inflammation highlighted in diabetes.GM-CSF-neuroantigen fusion proteins reverse experimental autoimmune encephalomyelitis and mediate tolerogenic activity in adjuvant-primed environments: association with inflammation-dependent, inhibitory antigen presentation.Use of nonobese diabetic mice to understand human type 1 diabetesNon-Th2 regulatory T-cell control of Th1 autoimmunity.The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetesInhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.Modeling CTLA4-linked autoimmunity with RNA interference in miceAltering immune tolerance therapeutically: the power of negative thinking.Breakdown in peripheral tolerance in type 1 diabetes in mice and humansFunctional deficiencies of granulocyte-macrophage colony stimulating factor and interleukin-3 contribute to insulitis and destruction of beta cells.OX40 costimulation turns off Foxp3+ Tregs.CTLA4 gene polymorphism and autoimmunity.The B7/CD28 costimulatory family in autoimmunity.Tissue expression of PD-L1 mediates peripheral T cell tolerance.Preventive treatment with methylprednisolone paradoxically exacerbates experimental autoimmune encephalomyelitis.Checkpoint blockade in cancer immunotherapyAccelerated type 1 diabetes induction in mice by adoptive transfer of diabetogenic CD4+ T cells.Co-stimulatory and Co-inhibitory Pathways in Autoimmunity.At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapyThe net effect of costimulatory blockers is dependent on the subset and activation status of the autoreactive T cells.Taming tissue-specific T cells: CTLA-4 reins in self-reactive T cells.Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 familyTreg and CTLA-4: two intertwining pathways to immune tolerance.Immunometabolic Regulations Mediated by Coinhibitory Receptors and Their Impact on T Cell Immune Responses.Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells.Thymocyte-derived BDNF influences T-cell maturation at the DN3/DN4 transition stage.Inhibition of the proteasome reduces transfer-induced diabetes in nonobese diabetic mice.CTLA-4 expressed by FOXP3+ regulatory T cells prevents inflammatory tissue attack and not T-cell priming in arthritis.Type 1 Diabetes: A Chronic Anti-Self-Inflammatory Response.Modulation of Alloimmune Responses by Interleukin-10 Prevents Rejection of Implanted Allogeneic Smooth Muscle Cells and Restores Postinfarction Ventricular Function.Serum sCTLA-4 levels and clinical manifestations in ankylosing spondylitis patientsPD-1 deficiency results in the development of fatal myocarditis in MRL micec-MIR, a Human E3 Ubiquitin Ligase, Is a Functional Homolog of Herpesvirus Proteins MIR1 and MIR2 and Has Similar Activity
P2860
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P2860
Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells
description
2000 nî lūn-bûn
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2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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Pinpointing when T cell costim ...... to dampen diabetogenic T cells
@ast
Pinpointing when T cell costim ...... to dampen diabetogenic T cells
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type
label
Pinpointing when T cell costim ...... to dampen diabetogenic T cells
@ast
Pinpointing when T cell costim ...... to dampen diabetogenic T cells
@en
prefLabel
Pinpointing when T cell costim ...... to dampen diabetogenic T cells
@ast
Pinpointing when T cell costim ...... to dampen diabetogenic T cells
@en
P2093
P2860
P356
P1476
Pinpointing when T cell costim ...... to dampen diabetogenic T cells
@en
P2093
P2860
P304
12204-12209
P356
10.1073/PNAS.200348397
P407
P577
2000-10-01T00:00:00Z