Herpes simplex virus 1 gamma(1)34.5 gene function, which blocks the host response to infection, maps in the homologous domain of the genes expressed during growth arrest and DNA damage.
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The herpes simplex virus type 1 U(S)11 protein interacts with protein kinase R in infected cells and requires a 30-amino-acid sequence adjacent to a kinase substrate domainGrowth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 proteinNck-1 antagonizes the endoplasmic reticulum stress-induced inhibition of translationA conserved domain of herpes simplex virus ICP34.5 regulates protein phosphatase complex in mammalian cellsInteraction between DNA-damage protein GADD34 and a new member of the Hsp40 family of heat shock proteins that is induced by a DNA-damaging reagentA herpesvirus genetic element which affects translation in the absence of the viral GADD34 functionIntelligent design: combination therapy with oncolytic virusesComplete sequence and comparative analysis of the genome of herpes B virus (Cercopithecine herpesvirus 1) from a rhesus monkeyHuman cytomegalovirus infection activates and regulates the unfolded protein response.An African swine fever virus virulence-associated gene NL-S with similarity to the herpes simplex virus ICP34.5 geneAutophagy, antiviral immunity, and viral countermeasuresGadd34 functional domains involved in growth suppression and apoptosisFeedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alphaThe herpes simplex virus type 1 vhs-UL41 gene secures viral replication by temporarily evading apoptotic cellular response to infection: Vhs-UL41 activity might require interactions with elements of cellular mRNA degradation machinery.A herpesvirus ribosome-associated, RNA-binding protein confers a growth advantage upon mutants deficient in a GADD34-related function.Herpes simplex virus 1 infection activates the endoplasmic reticulum resident kinase PERK and mediates eIF-2alpha dephosphorylation by the gamma(1)34.5 protein.Regulation of translation initiation following stress.Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with gamma 134.5- mutants of herThe second-site mutation in the herpes simplex virus recombinants lacking the gamma134.5 genes precludes shutoff of protein synthesis by blocking the phosphorylation of eIF-2alphaThe herpes simplex virus US11 protein effectively compensates for the gamma1(34.5) gene if present before activation of protein kinase R by precluding its phosphorylation and that of the alpha subunit of eukaryotic translation initiation factor 2.Functional interaction between fluorodeoxyuridine-induced cellular alterations and replication of a ribonucleotide reductase-negative herpes simplex virus.AlaArg motif in the carboxyl terminus of the gamma(1)34.5 protein of herpes simplex virus type 1 is required for the formation of a high-molecular-weight complex that dephosphorylates eIF-2alpha.A herpes simplex virus type 1 gamma34.5 second-site suppressor mutant that exhibits enhanced growth in cultured glioblastoma cells is severely attenuated in animalsImpact of tumor microenvironment on oncolytic viral therapyToxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma.HSV-1-based vectors for gene therapy of neurological diseases and brain tumors: part I. HSV-1 structure, replication and pathogenesis.Preparing an oncolytic poliovirus recombinant for clinical application against glioblastoma multiformeActivated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1Second-site mutation outside of the U(S)10-12 domain of Deltagamma(1)34.5 herpes simplex virus 1 recombinant blocks the shutoff of protein synthesis induced by activated protein kinase R and partially restores neurovirulence.Signals that dictate nuclear, nucleolar, and cytoplasmic shuttling of the gamma(1)34.5 protein of herpes simplex virus type 1Cisplatin-induced GADD34 upregulation potentiates oncolytic viral therapy in the treatment of malignant pleural mesotheliomaStructure and sequence of the saimiriine herpesvirus 1 genome.Molecular pathways of protein synthesis inhibition during brain reperfusion: implications for neuronal survival or death.Strain-dependent structural variants of herpes simplex virus type 1 ICP34.5 determine viral plaque size, efficiency of glycoprotein processing, and viral release and neuroinvasive disease potential2-aminopurine enhances the oncolytic activity of an E1b-deleted adenovirus in hepatocellular carcinoma cells.ICP34.5 protein of herpes simplex virus facilitates the initiation of protein translation by bridging eukaryotic initiation factor 2alpha (eIF2alpha) and protein phosphatase 1Identity of zinc finger nucleases with specificity to herpes simplex virus type II genomic DNA: novel HSV-2 vaccine/therapy precursorsReplication of herpes simplex virus 1 depends on the gamma 134.5 functions that facilitate virus response to interferon and egress in the different stages of productive infection.Herpesviruses and autophagy: catch me if you can!
P2860
Q24292276-C8AD69EC-3756-4060-A741-3C359A304CD3Q24293501-A47600DF-C595-41FA-B0A0-0A4339DE075FQ24300342-6BF46C6C-DE61-4967-A85B-DC1F9755B810Q24301971-F706462B-9B6E-40D1-BFD5-FB5E07F58788Q24302506-E4F5BD32-B747-435A-8A77-C6FEACB5B5B2Q24532229-3B1DDFF1-199F-44DB-96BD-55B8EBDBEDABQ24562045-67C82D6D-8E9A-4AAF-8025-025FADF2FDB8Q24628227-6D195C46-9F4B-4390-9576-5BB289124FEFQ24675195-0F61A32D-00DB-4B2F-8DFF-B04E2B1601FCQ27469611-3E9FAF3F-DF2A-4434-B1C4-78F845D5F012Q27480762-F1B5B6B8-0074-401B-ACE4-5382F15238FEQ27489559-874C1ADC-9BC8-4311-927D-6178726A171AQ28180042-10A62B8B-729B-44E0-8579-A0BEC53A51A2Q28512201-D5A2A8E5-B74B-4DC9-9F51-DBEF08577ED7Q33229421-3A19AF10-E5D7-4898-95A2-F4E402C145C7Q33645237-6EAA9694-4336-4466-AF02-C529C946857FQ33717136-2B5A5B05-A51B-494B-B0AB-D36DB665B1F0Q33771758-3C024ECF-1ED6-4F60-AED0-7DA892F20F7EQ33780588-1FA5ACF4-6A32-49C4-80D4-B76DCEE32CA6Q33783719-AFBA59B6-734D-4269-BDDB-3C1BBB02DCB6Q33785225-013AFD4F-44E0-47A8-A90F-F5A5F626A458Q33844465-FF3F3AC9-6847-407F-AAFC-8CC0B3349B38Q33851189-1922C9CF-309F-4C6D-A9D9-9888E421D24FQ33851852-91D09B67-BC38-45E6-8064-13B43F00669BQ33895533-7A9DCD9E-627C-4AD3-9959-515D2A3CA905Q33905047-D3E11F48-B888-429B-8B0D-98B759849C78Q33995747-73C90AB0-8C48-45CE-B42F-A9FFD1F70C42Q34105106-45829DC0-ACA4-4B5C-9829-012C850CBC58Q34302130-5E03B2C2-6F88-4D3B-BC39-350CAAB99AF3Q34328502-C1AD208C-B6B8-476C-A042-6E1871097D6BQ34344979-AE0350B8-AA0F-4AB8-8C81-39515883BF38Q34411569-59A79FFC-B930-4B9C-9FB2-E9C54AEBD0C0Q34474333-3EBE9332-D831-4CA3-B114-31B73D64E48EQ34514357-E0A3C66E-52FA-48D7-BC60-C046B257F450Q34744709-3E9B9A4D-39E6-40AC-8F2D-C70719355BCCQ34764233-4971B594-28BE-49B2-A4BC-1E848A143097Q35107434-1AA37A2B-1CE7-4E17-866B-B18596529183Q35111489-B4078866-3A09-4A6B-B38F-3CB65B134925Q35123297-8411BF92-CB8B-4C57-B692-2183E67764A3Q35260271-DF99FD47-4412-4AEB-B393-AF17308EBDAA
P2860
Herpes simplex virus 1 gamma(1)34.5 gene function, which blocks the host response to infection, maps in the homologous domain of the genes expressed during growth arrest and DNA damage.
description
1994 nî lūn-bûn
@nan
1994 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Herpes simplex virus 1 gamma(1 ...... growth arrest and DNA damage.
@ast
Herpes simplex virus 1 gamma(1 ...... growth arrest and DNA damage.
@en
type
label
Herpes simplex virus 1 gamma(1 ...... growth arrest and DNA damage.
@ast
Herpes simplex virus 1 gamma(1 ...... growth arrest and DNA damage.
@en
prefLabel
Herpes simplex virus 1 gamma(1 ...... growth arrest and DNA damage.
@ast
Herpes simplex virus 1 gamma(1 ...... growth arrest and DNA damage.
@en
P2860
P356
P1476
Herpes simplex virus 1 gamma(1 ...... growth arrest and DNA damage.
@en
P2093
P2860
P304
P356
10.1073/PNAS.91.12.5247
P407
P577
1994-06-01T00:00:00Z