Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry - Wikidata - wikimedia - TriplyDB

Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry

Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry

http://www.wikidata.org/entity/Q35514214

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Neuropathology and animal models of autism: genetic and environmental factors Altered Neuronal and Circuit Excitability in Fragile X Syndrome.Synaptic plasticity, neural circuits, and the emerging role of altered short-term information processing in schizophrenia.Following the genes: a framework for animal modeling of psychiatric disorders The contribution of inhibitory interneurons to circuit dysfunction in Fragile X Syndrome The pathophysiology of fragile X (and what it teaches us about synapses)Channelopathies and dendritic dysfunction in fragile X syndrome.Targeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromes Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome.Therapeutic Strategies in Fragile X Syndrome: From Bench to Bedside and Back A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model.Sensory processing in autism spectrum disorders and Fragile X syndrome-From the clinic to animal models.MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders.Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice.Degraded speech sound processing in a rat model of fragile X syndrome Auditory processing in fragile x syndrome.Investigating mechanisms underlying neurodevelopmental phenotypes of autistic and intellectual disability disorders: a perspective.Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome.Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome.Circuit level defects in the developing neocortex of Fragile X mice.Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons Neural synchronization deficits linked to cortical hyper-excitability and auditory hypersensitivity in fragile X syndrome Acamprosate in a mouse model of fragile X syndrome: modulation of spontaneous cortical activity, ERK1/2 activation, locomotor behavior, and anxiety Cerebellar Development and Autism Spectrum Disorder in Tuberous Sclerosis Complex.mTORC1 Is a Local, Postsynaptic Voltage Sensor Regulated by Positive and Negative Feedback Pathways.Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism Deficient tonic GABAergic conductance and synaptic balance in the fragile X syndrome amygdala Glutamate induces the elongation of early dendritic protrusions via mGluRs in wild type mice, but not in fragile X mice.Molecular Advances Leading to Treatment Implications for Fragile X Premutation Carriers Activity-dependent FMRP requirements in development of the neural circuitry of learning and memory.Deficits in tactile learning in a mouse model of fragile X syndrome.Selective role of the catalytic PI3K subunit p110β in impaired higher order cognition in fragile X syndrome.Pathological plasticity in fragile X syndrome.Elevated CaMKIIα and Hyperphosphorylation of Homer Mediate Circuit Dysfunction in a Fragile X Syndrome Mouse Model.Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism Analysis of Proteins That Rapidly Change Upon Mechanistic/Mammalian Target of Rapamycin Complex 1 (mTORC1) Repression Identifies Parkinson Protein 7 (PARK7) as a Novel Protein Aberrantly Expressed in Tuberous Sclerosis Complex (TSC)A target cell-specific role for presynaptic Fmr1 in regulating glutamate release onto neocortical fast-spiking inhibitory neurons.Sensory hypo-excitability in a rat model of fetal development in Fragile X Syndrome.APP Causes Hyperexcitability in Fragile X Mice.

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Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry

http://www.wikidata.org/entity/Q35514214

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2011 nî lūn-bûn

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2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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JNEUROSCI.3157-11.2011

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Journal of Neuroscience

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Altered neocortical rhythmic a ...... hanges in excitatory circuitry

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Jay R Gibson

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Kimberly M Huber

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Seth A Hays

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P2860

Correction of fragile X syndrome in mice.

Altered synaptic plasticity in a mouse model of fragile X mental retardation

Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function

A decade of molecular studies of fragile X syndrome

From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits

Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP

Visual experience regulates transient expression and dendritic localization of fragile X mental retardation protein

Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1

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14223-14234

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10.1523/JNEUROSCI.3157-11.2011

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