Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans.
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A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor αThe actin-bundling protein L-plastin supports T-cell motility and activationNSP-CAS Protein Complexes: Emerging Signaling Modules in CancerLack of bcr and abr promotes hypoxia-induced pulmonary hypertension in miceEGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis.Regulation of fibroblast lipid storage and myofibroblast phenotypes during alveolar septation in miceProapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cellsSema3C promotes the survival and tumorigenicity of glioma stem cells through Rac1 activation.Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion.A critical role for PDGFRα signaling in medial nasal process development.Evidence for post-translational processing of vascular endothelial (VE)-cadherin in brain tumors: towards a candidate biomarker.FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells.Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis.Protein kinase A-dependent phosphorylation of Dock180 at serine residue 1250 is important for glioma growth and invasion stimulated by platelet derived-growth factor receptor α.The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.Platelet Extracellular Regulated Protein Kinase 5 Is a Redox Switch and Triggers Maladaptive Platelet Responses and Myocardial Infarct ExpansionSrc family kinases differentially influence glioma growth and motilityRac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis.Rab23 promotes squamous cell carcinoma cell migration and invasion via integrin β1/Rac1 pathway.Prediction of functional phosphorylation sites by incorporating evolutionary informationRHPN2 drives mesenchymal transformation in malignant glioma by triggering RhoA activation.SHP-2-upregulated ZEB1 is important for PDGFRα-driven glioma epithelial-mesenchymal transition and invasion in mice and humans.EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180.Dock protein family in brain development and neurological disease.An EGFR wild type-EGFRvIII-HB-EGF feed-forward loop regulates the activation of EGFRvIII.The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion.Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction.Implications of Rho GTPase Signaling in Glioma Cell Invasion and Tumor Progression.Insights into the biological functions of Dock family guanine nucleotide exchange factors.I'm coming to GEF you: Regulation of RhoGEFs during cell migration.Ephrin-Bs Drive Junctional Downregulation and Actin Stress Fiber Disassembly to Enable Wound Re-epithelialization.Understanding the developmental pathways pulmonary fibroblasts may follow during alveolar regeneration.Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas and triggers Rac1-mediated tumour cell invasiveness.Downregulation of DOCK1 sensitizes bladder cancer cells to cisplatin through preventing epithelial-mesenchymal transition.Regulatory role of guanine nucleotide exchange factor (GEF) Dock180 phosphorylation on Tyr/Ser in mediation of gastric mucosal Rac1 activation in response to Helicobacter pylori and ghrelin.High expression of dedicator of cytokinesis 1 (DOCK1) confers poor prognosis in acute myeloid leukemia.Molecular Determinants of Malignant Brain Cancers: From Intracellular Alterations to Invasion Mediated by Extracellular Vesicles.TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma.Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding.PDGFR inhibition mediated intracellular signalling in C6 glioma growth and migration: role of ERK and ROCK pathway.
P2860
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P2860
Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Activation of Rac1 by Src-depe ...... origenesis in mice and humans.
@ast
Activation of Rac1 by Src-depe ...... origenesis in mice and humans.
@en
type
label
Activation of Rac1 by Src-depe ...... origenesis in mice and humans.
@ast
Activation of Rac1 by Src-depe ...... origenesis in mice and humans.
@en
prefLabel
Activation of Rac1 by Src-depe ...... origenesis in mice and humans.
@ast
Activation of Rac1 by Src-depe ...... origenesis in mice and humans.
@en
P2093
P2860
P356
P1476
Activation of Rac1 by Src-depe ...... origenesis in mice and humans.
@en
P2093
Haizhong Feng
Jann N Sarkaria
Jia-Jean Yiin
Kristiina Vuori
Kun-Wei Liu
Motoo Nagane
Ronald L Hamilton
Ryo Nishikawa
Shi-Yuan Cheng
P2860
P304
P356
10.1172/JCI58559
P407
P577
2011-11-14T00:00:00Z