Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis.
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The epidermal growth factor receptor variant III (EGFRvIII): where wild things are alteredGefitinib selectively inhibits tumor cell migration in EGFR-amplified human glioblastomaIdentification of EGF-NF-κB-FOXC1 signaling axis in basal-like breast cancer.EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis.Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion.TGF-β/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasisTherapeutic control and resistance of the EGFR-driven signaling network in glioblastoma.Protein kinase A-dependent phosphorylation of Dock180 at serine residue 1250 is important for glioma growth and invasion stimulated by platelet derived-growth factor receptor α.Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells.Cooperation of distinct Rac-dependent pathways to stabilise E-cadherin adhesionRac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis.SHP-2-upregulated ZEB1 is important for PDGFRα-driven glioma epithelial-mesenchymal transition and invasion in mice and humans.MDA-9/syntenin is a key regulator of glioma pathogenesis.EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180.Dock protein family in brain development and neurological disease.The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion.Epidermal growth factor receptor as a therapeutic target in glioblastoma.Implications of Rho GTPase Signaling in Glioma Cell Invasion and Tumor Progression.Insights into the biological functions of Dock family guanine nucleotide exchange factors.I'm coming to GEF you: Regulation of RhoGEFs during cell migration.Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas and triggers Rac1-mediated tumour cell invasiveness.EGFR and EGFRvIII Promote Angiogenesis and Cell Invasion in Glioblastoma: Combination Therapies for an Effective Treatment.Downregulation of DOCK1 sensitizes bladder cancer cells to cisplatin through preventing epithelial-mesenchymal transition.The bipartite rac1 Guanine nucleotide exchange factor engulfment and cell motility 1/dedicator of cytokinesis 180 (elmo1/dock180) protects endothelial cells from apoptosis in blood vessel development.Transdifferentiation of glioblastoma stem-like cells into mural cells drives vasculogenic mimicry in glioblastomas.TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma.EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition.Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies.Targeting autophagy sensitises lung cancer cells to Src family kinase inhibitors.
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P2860
Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Phosphorylation of dedicator o ...... en glioblastoma tumorigenesis.
@ast
Phosphorylation of dedicator o ...... en glioblastoma tumorigenesis.
@en
type
label
Phosphorylation of dedicator o ...... en glioblastoma tumorigenesis.
@ast
Phosphorylation of dedicator o ...... en glioblastoma tumorigenesis.
@en
prefLabel
Phosphorylation of dedicator o ...... en glioblastoma tumorigenesis.
@ast
Phosphorylation of dedicator o ...... en glioblastoma tumorigenesis.
@en
P2093
P2860
P50
P356
P1476
Phosphorylation of dedicator o ...... en glioblastoma tumorigenesis.
@en
P2093
Careen K Tang
Haizhong Feng
Jann N Sarkaria
Kristiina Vuori
Michael J Jarzynka
Ronald L Hamilton
Ryo Nishikawa
Shi-Yuan Cheng
Susan Keezer
P2860
P304
P356
10.1073/PNAS.1121457109
P407
P577
2012-02-07T00:00:00Z