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PCAF modulates PTEN activityFeedback circuit among INK4 tumor suppressors constrains human glioblastoma developmentMicroRNA-138 modulates DNA damage response by repressing histone H2AX expressionHeterogeneity of epidermal growth factor receptor signalling networks in glioblastomaA drosophila model for EGFR-Ras and PI3K-dependent human gliomaA kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastomaA novel seven transmembrane receptor induced during the early steps of astrocyte differentiation identified by differential expressionPHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growthMalignant astrocytic glioma: genetics, biology, and paths to treatmentEpidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalizationSETA: a novel SH3 domain-containing adapter molecule associated with malignancy in astrocytesNeutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling.Nuclear EGFRvIII-STAT5b complex contributes to glioblastoma cell survival by direct activation of the Bcl-XL promoter.Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastomaTargeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapyMutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence.PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3.Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA.Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma.An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain CancersCellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor.Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma.EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis.Malignant glioma: genetics and biology of a grave matter.Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing.Analysis of phosphotyrosine signaling in glioblastoma identifies STAT5 as a novel downstream target of ΔEGFR.Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma.A urokinase receptor-Bim signaling axis emerges during EGFR inhibitor resistance in mutant EGFR glioblastoma.Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressorHeterogeneity maintenance in glioblastoma: a social networkA unified nomenclature and amino acid numbering for human PTEN.Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells.Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans.Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma.Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis.Phosphotyrosine signaling analysis of site-specific mutations on EGFRvIII identifies determinants governing glioblastoma cell growthOrthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition.Emerging insights into the molecular and cellular basis of glioblastoma.Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations.Unconventional processing of the 3' termini of the Epstein-Barr virus DNA polymerase mRNA.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Frank B Furnari
@ast
Frank B Furnari
@en
Frank B Furnari
@es
Frank B Furnari
@nl
type
label
Frank B Furnari
@ast
Frank B Furnari
@en
Frank B Furnari
@es
Frank B Furnari
@nl
prefLabel
Frank B Furnari
@ast
Frank B Furnari
@en
Frank B Furnari
@es
Frank B Furnari
@nl
P106
P21
P31
P496
0000-0003-1909-4361