Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice. - Wikidata - wikimedia - TriplyDB

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice.

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice.

http://www.wikidata.org/entity/Q35574384

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Reelin Proteolysis Affects Signaling Related to Normal Synapse Function and Neurodegeneration NDUFA12L mitochondrial complex-I assembly factor: Implications for taupathies The Metamorphic Nature of the Tau Protein: Dynamic Flexibility Comes at a Cost Tau Oligomers: The Toxic Player at Synapses in Alzheimer's Disease Tangles, Toxicity, and Tau Secretion in AD - New Approaches to a Vexing Problem Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model Rescue from tau-induced neuronal dysfunction produces insoluble tau oligomers Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits Tau physiology and pathomechanisms in frontotemporal lobar degeneration Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast-Induced Traumatic Brain Injury Alzheimer disease: a tale of two prions Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo.Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease.Roles of tau protein in health and disease.Identification of oligomers at early stages of tau aggregation in Alzheimer's disease.Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer's Disease and Related Tauopathies.Human cyclophilin 40 unravels neurotoxic amyloids.Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice The intersection of amyloid beta and tau at synapses in Alzheimer's disease Protein tau: prime cause of synaptic and neuronal degeneration in Alzheimer's disease.Characterization of tau oligomeric seeds in progressive supranuclear palsy.The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes.Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice.PE859, a novel tau aggregation inhibitor, reduces aggregated tau and prevents onset and progression of neural dysfunction in vivo.Bimolecular fluorescence complementation; lighting-up tau-tau interaction in living cells.Isolation and characterization of antibody fragments selective for toxic oligomeric tau GSK3 and Alzheimer's Disease: Facts and Fiction….Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease Understanding the kinetic roles of the inducer heparin and of rod-like protofibrils during amyloid fibril formation by Tau protein The pathophysiology of repetitive concussive traumatic brain injury in experimental models; new developments and open questions Using intramolecular disulfide bonds in tau protein to deduce structural features of aggregation-resistant conformations.Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation Soluble forms of tau are toxic in Alzheimer's disease.Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases.Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons.Tau-Directed Immunotherapy: A Promising Strategy for Treating Alzheimer's Disease and Other Tauopathies.

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Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice.

http://www.wikidata.org/entity/Q35574384

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Molecular Neurodegeneration

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Audra L Clos

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Cristian A Lasagna-Reeves

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George R Jackson

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Rakez Kayed

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Urmi Sengupta

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P2860

Role of Protein Aggregation in Mitochondrial Dysfunction and Neurodegeneration in Alzheimer's and Parkinson's Diseases

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau

Transmission and spreading of tauopathy in transgenic mouse brain

Neuropathological stageing of Alzheimer-related changes

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

Neuron loss from the hippocampus of Alzheimer's disease exceeds extracellular neurofibrillary tangle formation

Common mechanisms of amyloid oligomer pathogenesis in degenerative disease

Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment

Tau suppression in a neurodegenerative mouse model improves memory function

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10.1186/1750-1326-6-39

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Diana L Castillo-Carranza

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51195574

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