Molecular cloning of the neu gene: absence of gross structural alteration in oncogenic alleles.
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P1343
Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gammaActivated neu oncogene sequences in primary tumors of the peripheral nervous system induced in rats by transplacental exposure to ethylnitrosoureaDominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/NeuA chimeric EGF-R-neu proto-oncogene allows EGF to regulate neu tyrosine kinase and cell transformation.Transcriptional repression of the neu protooncogene by the adenovirus 5 E1A gene products.Phosphorylation process induced by epidermal growth factor alters the oncogenic and cellular neu (NGL) gene products.Increased tyrosine kinase activity associated with the protein encoded by the activated neu oncogene.Amplification of the proto-neu oncogene facilitates oncogenic activation by a single point mutation.Experimental approaches to hypothetical hormones: detection of a candidate ligand of the neu protooncogene.HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression.Effective tumor immunotherapy directed against an oncogene-encoded product using a vaccinia virus vector.Stage- and tissue-specific expression of the neu oncogene in rat development.Distinctive transforming genes in x-ray-transformed mammalian cells.Cell cycle-dependent regulation of p185neu: a relationship between disruption of this regulation and transformation.Role of extracellular subdomains of p185c-neu and the epidermal growth factor receptor in ligand-independent association and transactivationThe role of distinct p185neu extracellular subdomains for dimerization with the epidermal growth factor (EGF) receptor and EGF-mediated signaling.Reduced risk of breast cancer associated with recreational physical activity varies by HER2 status.ErbB2 induces Notch1 activity and function in breast cancer cellsIdentification and characterization of a novel enhancer for the rat neu promoter.Transformation of NIH 3T3 cells by overexpression of the normal coding sequence of the rat neu gene.Multiple cis- and trans-acting elements involved in regulation of the neu gene.Negative autoregulation of the neu gene is mediated by a novel enhancer.Oncogenic activation of p185neu stimulates tyrosine phosphorylation in vivop185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activityAdenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogeneC-erbB-2 immunostaining: problems with interpretationClinical applications of mouse models for breast cancer engaging HER2/neu.Agonistic antibodies stimulate the kinase encoded by the neu protooncogene in living cells but the oncogenic mutant is constitutively activeTwo motifs within a transmembrane domain, one for homodimerization and the other for heterodimerization.Oncogenic and tumor-suppressive mouse models for breast cancer engaging HER2/neu.Human cancer and cellular oncogenes.Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene.Characterization of a repressor element and a juxtaposed tissue-restricted activator element located on the distal neu gene promoter.A chimeric EGFR/neu receptor in functional analysis of the neu oncoprotein.Roles for a cytoplasmic tyrosine and tyrosine kinase activity in the interactions of Neu receptors with coated pits.Heregulin stimulates mitogenesis and phosphatidylinositol 3-kinase in mouse fibroblasts transfected with erbB2/neu and erbB3.Oncogenic activation of the neu-encoded receptor protein by point mutation and deletionMitosis-specific negative regulation of epidermal growth factor receptor, triggered by a decrease in ligand binding and dimerization, can be overcome by overexpression of receptor.Receptor downregulation and DNA synthesis are modulated by EGF and TPA in cells expressing an EGFR/neu chimera.The N-terminal common domain of simian virus 40 large T and small t antigens acts as a transformation suppressor of the HER-2/neu oncogene.
P2860
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P2860
Molecular cloning of the neu gene: absence of gross structural alteration in oncogenic alleles.
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Molecular cloning of the neu g ...... teration in oncogenic alleles.
@ast
Molecular cloning of the neu g ...... teration in oncogenic alleles.
@en
type
label
Molecular cloning of the neu g ...... teration in oncogenic alleles.
@ast
Molecular cloning of the neu g ...... teration in oncogenic alleles.
@en
prefLabel
Molecular cloning of the neu g ...... teration in oncogenic alleles.
@ast
Molecular cloning of the neu g ...... teration in oncogenic alleles.
@en
P2093
P2860
P356
P1476
Molecular cloning of the neu g ...... teration in oncogenic alleles.
@en
P2093
A L Schechter
P Y Chevray
R A Weinberg
P2860
P304
P356
10.1073/PNAS.83.2.261
P407
P4510
P577
1986-01-01T00:00:00Z