Understanding the role of TDP-43 and FUS/TLS in ALS and beyond.
about
Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative diseaseFrontotemporal Lobar Degeneration and MicroRNAsInduced pluripotent stem cells for modeling neurological disordersResveratrol: A Focus on Several Neurodegenerative DiseasesYeast prions and human prion-like proteins: sequence features and prediction methodsConverging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisRNA protein interaction in neuronsDoes a loss of TDP-43 function cause neurodegeneration?Interaction of RNA with a C-terminal fragment of the amyotrophic lateral sclerosis-associated TDP43 reduces cytotoxicityTDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegansThe neurogenetics of alternative splicingRNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosisEngineering enhanced protein disaggregases for neurodegenerative diseaseALS-linked mutations in ubiquilin-2 or hnRNPA1 reduce interaction between ubiquilin-2 and hnRNPA1Mitochondrial dysfunction in neurodegenerative diseasesA comprehensive library of familial human amyotrophic lateral sclerosis induced pluripotent stem cellsFUS Interacts with HSP60 to Promote Mitochondrial DamageNucleic acid-binding specificity of human FUS protein.ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLDRecruitment into stress granules prevents irreversible aggregation of FUS protein mislocalized to the cytoplasmHighly efficient cell-type-specific gene inactivation reveals a key function for the Drosophila FUS homolog cabeza in neuronsMutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis.The ALS gene FUS regulates synaptic transmission at the Drosophila neuromuscular junction.Intricate effects of primary motor neuronopathy on contractile proteins and metabolic muscle enzymes as revealed by label-free mass spectrometry.Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects.The potential for transition metal-mediated neurodegeneration in amyotrophic lateral sclerosisNuclear TAR DNA-binding protein 43: A new target for amyotrophic lateral sclerosis treatmentMultistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanisms.The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease.The emerging roles of microRNAs in the pathogenesis of frontotemporal dementia-amyotrophic lateral sclerosis (FTD-ALS) spectrum disordersDysregulation of the proteasome increases the toxicity of ALS-linked mutant SOD1.Transposable elements in TDP-43-mediated neurodegenerative disorders.Analysis of nuclear export sequence regions of FUS-Related RNA-binding proteins in essential tremorPur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity.Sequestration of cellular interacting partners by protein aggregates: implication in a loss-of-function pathology.Characterization of FUS mutations in amyotrophic lateral sclerosis using RNA-Seq.TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA.Psychiatric genetics, neurogenetics, and neurodegenerationPARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage.
P2860
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P2860
Understanding the role of TDP-43 and FUS/TLS in ALS and beyond.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Understanding the role of TDP-43 and FUS/TLS in ALS and beyond.
@ast
Understanding the role of TDP-43 and FUS/TLS in ALS and beyond.
@en
type
label
Understanding the role of TDP-43 and FUS/TLS in ALS and beyond.
@ast
Understanding the role of TDP-43 and FUS/TLS in ALS and beyond.
@en
prefLabel
Understanding the role of TDP-43 and FUS/TLS in ALS and beyond.
@ast
Understanding the role of TDP-43 and FUS/TLS in ALS and beyond.
@en
P2860
P1476
Understanding the role of TDP-43 and FUS/TLS in ALS and beyond
@en
P2093
Sandrine Da Cruz
P2860
P304
P356
10.1016/J.CONB.2011.05.029
P577
2011-08-02T00:00:00Z