about
Chromosomal clustering of genes controlled by the aire transcription factor.E3 ubiquitin ligases and their control of T cell autoreactivityStructure of a TCR with high affinity for self-antigen reveals basis for escape from negative selectionHow defects in central tolerance impinge on a deficiency in regulatory T cellsTSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentationRegulation of T cell development and activation by creatine kinase B.c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway.TCR recognition of peptide/MHC class II complexes and superantigensVitamin D responsive elements within the HLA-DRB1 promoter region in Sardinian multiple sclerosis associated alleles.Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunityInflammatory disease and lymphomagenesis caused by deletion of the Myc antagonist Mnt in T cells.Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunityParallels and distinctions between T and NKT cell development in the thymus.c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.Modifier loci condition autoimmunity provoked by Aire deficiency.Autoimmunity: basic mechanisms and implications in endocrine diseases. Part I.Recognition of self-peptide-MHC complexes by autoimmune T-cell receptors.Vaccination against self to prevent autoimmune disease: the type 1 diabetes model.Advances in type I diabetes associated tolerance mechanisms.Tumor immune therapy: lessons from infection and implications for cancer - can IL-7 help overcome immune inhibitory networks?Structural basis for self-recognition by autoimmune T-cell receptors.T Regulatory Cell Biology in Health and Disease.Beyond the Oncogene Revolution: Four New Ways to Combat Cancer.Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.Thymic self-antigen expression for the design of a negative/tolerogenic self-vaccine against type 1 diabetes
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Negative selection and autoimmunity.
@ast
Negative selection and autoimmunity.
@en
type
label
Negative selection and autoimmunity.
@ast
Negative selection and autoimmunity.
@en
prefLabel
Negative selection and autoimmunity.
@ast
Negative selection and autoimmunity.
@en
P1476
Negative selection and autoimmunity.
@en
P2093
Pamela S Ohashi
P304
P356
10.1016/J.COI.2003.09.013
P577
2003-12-01T00:00:00Z