Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.
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Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligasesMutant Cbl proteins as oncogenic drivers in myeloproliferative disordersc-Cbl-mediated regulation of LAT-nucleated signaling complexesc-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway.CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic developmentCbl and human myeloid neoplasms: the Cbl oncogene comes of age.c-Cbl deficiency leads to diminished lymphocyte development and functions in an age-dependent manner.Loss of Cbl-PI3K interaction in mice prevents significant bone loss following ovariectomyRapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.p85beta phosphoinositide 3-kinase regulates CD28 coreceptor functionUnaltered negative selection and Treg development of self-reactive thymocytes in TCR transgenic Fyn-deficient mice.The loss of Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival.Indispensable roles of mammalian Cbl family proteins as negative regulators of protein tyrosine kinase signaling: Insights from in vivo modelsDasatinib targets B-lineage cells but does not provide an effective therapy for myeloproliferative disease in c-Cbl RING finger mutant mice.The E3 ligase c-Cbl regulates dendritic cell activationCD8+ T cells are associated with severe gastritis in Helicobacter pylori-infected mice in the absence of CD4+ T cellsThe E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells.c-Cbl expression levels regulate the functional responses of human central and effector memory CD4 T cellsLymphocyte signaling: beyond knockouts.Degradation of activated protein kinases by ubiquitination.A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells.Shaping the T-cell repertoire: a matter of life and death.Cbl-family proteins as regulators of cytoskeleton-dependent phenomena.Cell regulation by phosphotyrosine-targeted ubiquitin ligases.CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling via elevated levels of JAK2 and LYN.Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy.VAV1-Cre mediated hematopoietic deletion of CBL and CBL-B leads to JMML-like aggressive early-neonatal myeloproliferative disease.A specific signalling signature characterizes the development of naturally occurring and antigen-specific regulatory T cells.Thymic alterations in mice deficient for the SNARE protein VAMP8/endobrevin.
P2860
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P2860
Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
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2005年學術文章
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2005年學術文章
@zh-hant
name
Loss of c-Cbl RING finger func ...... signaling and thymic deletion.
@en
Loss of c-Cbl RING finger func ...... signaling and thymic deletion.
@nl
type
label
Loss of c-Cbl RING finger func ...... signaling and thymic deletion.
@en
Loss of c-Cbl RING finger func ...... signaling and thymic deletion.
@nl
prefLabel
Loss of c-Cbl RING finger func ...... signaling and thymic deletion.
@en
Loss of c-Cbl RING finger func ...... signaling and thymic deletion.
@nl
P2093
P2860
P50
P356
P1433
P1476
Loss of c-Cbl RING finger func ...... signaling and thymic deletion
@en
P2093
Christine B F Thien
Frøydis D Blystad
Valentina Voigt
Wallace Y Langdon
P2860
P304
P356
10.1038/SJ.EMBOJ.7600841
P407
P577
2005-10-06T00:00:00Z