Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate.
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International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapySignaling of the Human P2Y(1) Receptor Measured by a Yeast Growth Assay with Comparisons to Assays of Phospholipase C and Calcium Mobilization in 1321N1 Human Astrocytoma CellsMethanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptorsSecond messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptorDesign and synthesis of new bicyclic diketopiperazines as scaffolds for receptor probes of structurally diverse functionality.Molecular recognition at purine and pyrimidine nucleotide (P2) receptors.Development of selective agonists and antagonists of P2Y receptors.Molecular probes for muscarinic receptors: functionalized congeners of selective muscarinic antagonistsPharmacochemistry of the platelet purinergic receptors.Functionalized congener approach to the design of ligands for G protein-coupled receptors (GPCRs).Cross-linked polymeric nanogel formulations of 5'-triphosphates of nucleoside analogues: role of the cellular membrane in drug release.Nomenclature and classification of purinoceptors.Differential effects of P2-purinoceptor antagonists on phospholipase C- and adenylyl cyclase-coupled P2Y-purinoceptors.Development of selective high affinity antagonists, agonists, and radioligands for the P2Y1 receptor.Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors.Molecular recognition at adenine nucleotide (P2) receptors in platelets.Potent agonist action of 2-thioether derivatives of adenine nucleotides at adenylyl cyclase-linked P2Y-purinoceptors.Identification of potent P2Y-purinoceptor agonists that are derivatives of adenosine 5'-monophosphate.Activity of Novel Adenine Nucleotide Derivatives as Agonists and Antagonists at Recombinant Rat P2X ReceptorsStructure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor2-Substituted adenosine derivatives: affinity and efficacy at four subtypes of human adenosine receptors.2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists.A mutational analysis of residues essential for ligand recognition at the human P2Y1 receptor.Structure Activity Relationships for Derivatives of Adenosine-5'-Triphosphate as Agonists at P(2) Purinoceptors: Heterogeneity Within P(2X) and P(2Y) SubtypesFunctionalized congeners of 1,4-dihydropyridines as antagonist molecular probes for A3 adenosine receptorsModelling the P2Y purinoceptor using rhodopsin as templateThe role of amino acids in extracellular loops of the human P2Y1 receptor in surface expression and activation processes.Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites.The therapeutic effect of 2-cyclohexylthio-AMP in heart failure.Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonistsSynthesis and cytostatic and antiviral activities of 2'-deoxy-2',2'-difluororibo- and 2'-deoxy-2'-fluororibonucleosides derived from 7-(Het)aryl-7-deazaadenines.Identification of a promising drug candidate for the treatment of type 2 diabetes based on a P2Y(1) receptor agonist.A novel insulin secretagogue based on a dinucleoside polyphosphate scaffold.Identification of hydrolytically stable and selective P2Y(1) receptor agonists.2'-C-Methyl branched pyrimidine ribonucleoside analogues: potent inhibitors of RNA virus replication.Fluorescent N2,N3-epsilon-adenine nucleoside and nucleotide probes: synthesis, spectroscopic properties, and biochemical evaluation.Subtype specific internalization of P2Y1 and P2Y2 receptors induced by novel adenosine 5'-O-(1-boranotriphosphate) derivatives.Purinoceptors: from history to recent progress. A review.Evidence for P2-purinoceptor-mediated inhibition of noradrenaline release in rat brain cortex.Facile small scale synthesis of nucleoside 5'-phosphate mixtures.
P2860
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P2860
Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Identification of potent, sele ...... of adenosine 5'-triphosphate.
@ast
Identification of potent, sele ...... of adenosine 5'-triphosphate.
@en
type
label
Identification of potent, sele ...... of adenosine 5'-triphosphate.
@ast
Identification of potent, sele ...... of adenosine 5'-triphosphate.
@en
prefLabel
Identification of potent, sele ...... of adenosine 5'-triphosphate.
@ast
Identification of potent, sele ...... of adenosine 5'-triphosphate.
@en
P2093
P2860
P356
P1476
Identification of potent, sele ...... of adenosine 5'-triphosphate.
@en
P2093
A L Brizzolara
A U Ziganshin
G Burnstock
G E Knight
K A Jacobson
T K Harden
P2860
P304
P356
10.1021/JM00076A023
P407
P577
1993-11-01T00:00:00Z