Fas-mediated apoptosis in cholangiocarcinoma cells is enhanced by 3,3'-diindolylmethane through inhibition of AKT signaling and FLICE-like inhibitory protein.
about
Identification of the Calmodulin-Binding Domains of Fas Death ReceptorCharacterization of calmodulin-Fas death domain interaction: an integrated experimental and computational study.Chemopreventive agent 3,3'-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases.PARP-1 regulates resistance of pancreatic cancer to TRAIL therapy.3,3'-diindolylmethane enhances the efficacy of butyrate in colon cancer prevention through down-regulation of survivinAttenuation of multi-targeted proliferation-linked signaling by 3,3'-diindolylmethane (DIM): from bench to clinic.Molecular mechanisms of tamoxifen therapy for cholangiocarcinoma: role of calmodulin.Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells.Prostate apoptosis response-4 is expressed in normal cholangiocytes, is down-regulated in human cholangiocarcinoma, and promotes apoptosis of neoplastic cholangiocytes when induced pharmacologically3,3'-Diindolylmethane exhibits antileukemic activity in vitro and in vivo through a Akt-dependent process.Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanismA study of mifepristone/IFN-γ-induced apoptosis of human cholangiocarcinoma cell line FRH-0201 in vitro.Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling.Antioxidant function of isoflavone and 3,3'-diindolylmethane: are they important for cancer prevention and therapy?Conformation and free energy analyses of the complex of calcium-bound calmodulin and the Fas death domainStructural and biophysical characterization of the interactions between the death domain of Fas receptor and calmodulin.Mechanisms and therapeutic implications of cell death induction by indole compounds.Targeted regulation of PI3K/Akt/mTOR/NF-κB signaling by indole compounds and their derivatives: mechanistic details and biological implications for cancer therapyIncreased activation of PI3K/AKT signaling pathway is associated with cholangiocarcinoma metastasis and PI3K/mTOR inhibition presents a possible therapeutic strategy.Reduced CaM/FLIP binding by a single point mutation in c-FLIP(L) modulates Fas-mediated apoptosis and decreases tumorigenesis.Calmodulin mediates Fas-induced FADD-independent survival signaling in pancreatic cancer cells via activation of Src-extracellular signal-regulated kinase (ERK).Tamoxifen enhances therapeutic effects of gemcitabine on cholangiocarcinoma tumorigenesis.Human cholangiocarcinoma development is associated with dysregulation of opioidergic modulation of cholangiocyte growth.Trifluoperazine regulation of calmodulin binding to Fas: a computational study.Pathobiology of biliary epithelia and cholangiocarcinoma: proceedings of the Henry M. and Lillian Stratton Basic Research Single-Topic Conference.Structural insight for the roles of fas death domain binding to FADD and oligomerization degree of the Fas-FADD complex in the death-inducing signaling complex formation: a computational study.
P2860
Q28552166-9855AB1C-7DA5-400D-BC6F-7A24C6A4BCA7Q33558240-5F7552F8-C78C-4983-ACD0-055ED3BC61C9Q33597363-C8DFE756-D9F0-4D3A-B5F1-2A3FD40941EBQ33731141-4CFBB3E0-F9BA-4CB1-8442-A49C50BD6A8EQ33980057-C06F9653-480A-4EBD-991D-8C5388B2001CQ33997903-FC9331C0-3CF7-4070-84BA-F67FD582B72BQ34000409-DA2EB0A4-E49C-4BFF-A560-4C631ADE333BQ34051616-91F5CAC5-B409-4C54-81F3-BAC0509A3A53Q34162371-317F377D-727B-4F1C-8E1F-D3B8009AF005Q34171365-6763E9B8-CE7C-4E05-B4A2-79643CB684FDQ35841978-7C12637F-88FA-40DB-94CD-A10259568972Q36398259-07AA59F2-EE03-4775-9F21-2EDE64850E94Q36678487-C2E83B75-7737-4A9F-A01B-9BF6CFDE09A8Q36945706-3DBF0264-A39A-40D4-A362-8880110153BDQ37008175-53797741-3D36-453E-A377-58D02F21E0CAQ37048442-6862C1A8-AE78-4B5D-A18B-B964ECA77133Q37137367-0E9CE257-0880-4641-99CE-128449A7FD43Q37512204-4FEAD0CD-E945-4502-8A69-9D1760A138C0Q39129195-04851CCA-4D6F-4934-A937-E17B09BDED9FQ39474971-CF48CF5C-9ADA-4EEA-A3AA-A70932583C6EQ39536531-9B6DE879-27B8-4F3D-BE80-11DBF7761D40Q39564543-2E308E70-7B43-4B2B-AD71-0C2C3CE84C71Q39926096-3C03D3E4-3831-4287-BD87-856734E84F89Q41850711-814C84C7-B13A-40FF-A779-9B6E14FE56FCQ42174609-C2AEDA94-66BF-499A-803F-2807B27A1058Q43014937-993953CD-EB83-49B6-B584-98809ACF87F4
P2860
Fas-mediated apoptosis in cholangiocarcinoma cells is enhanced by 3,3'-diindolylmethane through inhibition of AKT signaling and FLICE-like inhibitory protein.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Fas-mediated apoptosis in chol ...... FLICE-like inhibitory protein.
@ast
Fas-mediated apoptosis in chol ...... FLICE-like inhibitory protein.
@en
type
label
Fas-mediated apoptosis in chol ...... FLICE-like inhibitory protein.
@ast
Fas-mediated apoptosis in chol ...... FLICE-like inhibitory protein.
@en
prefLabel
Fas-mediated apoptosis in chol ...... FLICE-like inhibitory protein.
@ast
Fas-mediated apoptosis in chol ...... FLICE-like inhibitory protein.
@en
P2093
P2860
P1476
Fas-mediated apoptosis in chol ...... FLICE-like inhibitory protein.
@en
P2093
Chang-Hyun Byon
Jay M McDonald
Jianmin Xu
Nirag Jhala
Pritish Pawar
Yabing Chen
Zeng B Zhu
P2860
P304
P356
10.2353/AJPATH.2006.060234
P407
P577
2006-11-01T00:00:00Z