Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications. - Wikidata - wikimedia - TriplyDB

Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications.

Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications.

http://www.wikidata.org/entity/Q35651511

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Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay Mice with genetic type 2 diabetes Suppressors of Cytokine Signaling in Sickness and in Health of Pancreatic β-Cells Advances and challenges in the differentiation of pluripotent stem cells into pancreatic β cells Obestatin: a new metabolic player in the pancreas and white adipose tissue The streetlight effect in type 1 diabetes Variability in vascular smooth muscle cell stretch-induced responses in 2D culture Thyroid hormone T3 counteracts STZ induced diabetes in mouse WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells In vitro proliferation of adult human beta-cells A practical guide to rodent islet isolation and assessment 12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet Protein profiling of pancreatic islets.Exdpf is a key regulator of exocrine pancreas development controlled by retinoic acid and ptf1a in zebrafish.Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass.Combination treatment of db/db mice with exendin-4 and gastrin preserves β-cell mass by stimulating β-cell growth and differentiation.Current views on type 2 diabetes.Activation of GPR40 attenuates chronic inflammation induced impact on pancreatic β-cells health and function.Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation.Targeting cyclophilin D and the mitochondrial permeability transition enhances beta-cell survival and prevents diabetes in Pdx1 deficiency.Acute hyperglycemia does not impair microvascular reactivity and endothelial function during hyperinsulinemic isoglycemic and hyperglycemic clamp in type 1 diabetic patients Gene networks modified by sulphonylureas in beta cells: a pathway-based analysis of insulin secretion and cell death.Tumor necrosis factor-α induces transcriptional activation of nuclear factor-κB in insulin-producing β-cells Development of the endocrine pancreas and novel strategies for β-cell mass restoration and diabetes therapy.Mitochondrial dynamics in diabetes.Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis.Control of blood glucose in type 2 diabetes without weight loss by modification of diet composition.Oral but not intravenous glucose acutely decreases circulating interleukin-6 concentrations in overweight individuals Targeting GLP-1 receptors for repeated magnetic resonance imaging differentiates graded losses of pancreatic beta cells in mice.Type 1, type 1.5, and type 2 diabetes: NOD the diabetes we thought it was Diabetic complications and dysregulated innate immunity.Vitamin A deficiency causes hyperglycemia and loss of pancreatic β-cell mass.Interleukin-1 as a common denominator from autoinflammatory to autoimmune disorders: premises, perils, and perspectives Research resource: Monitoring endoplasmic reticulum membrane integrity in β-cells at the single-cell level.Pancreatic insulin-producing cells differentiated from human embryonic stem cells correct hyperglycemia in SCID/NOD mice, an animal model of diabetes Mitochondrial dysfunction and β-cell failure in type 2 diabetes mellitus.The Fas pathway is involved in pancreatic beta cell secretory function.Metabolic surgery and intestinal gene expression: Digestive tract and diabetes evolution considerations.Preserved C-peptide levels in overweight or obese compared with underweight children upon diagnosis of type 1 diabetes mellitus.The isolated pancreatic islet as a micro-organ and its transplantation to cure diabetes: celebrating the legacy of Paul Lacy.Cellular sources of new pancreatic beta cells and therapeutic implications for regenerative medicine.

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P2860

Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications.

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Increased islet apoptosis in Pdx1+/- mice

Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance

High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program

Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis

Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.

Islet growth and development in the adult.

FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication.

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