Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia.
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The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs)Phosphoflow-Based Evaluation of Mek Inhibitors as Small-Molecule Therapeutics for B-Cell Precursor Acute Lymphoblastic LeukemiaCysteine and glycine-rich protein 2 (CSRP2) transcript levels correlate with leukemia relapse and leukemia-free survival in adults with B-cell acute lymphoblastic leukemia and normal cytogenetics.PTEN opposes negative selection and enables oncogenic transformation of pre-B cells.Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling.The role of ZAP70 kinase in acute lymphoblastic leukemia infiltration into the central nervous system.Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia.Regulation of cardiac hypertrophy and remodeling through the dual-specificity MAPK phosphatases (DUSPs).Targeting Tyrosine Phosphatases: Time to End the Stigma.Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemiaGain-of-Function Mutations in the Toll-Like Receptor Pathway: TPL2-Mediated ERK1/ERK2 MAPK Activation, a Path to Tumorigenesis in Lymphoid Neoplasms?Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome.Dynamic pre-BCR homodimers fine-tune autonomous survival signals in B cell precursor acute lymphoblastic leukemia.A Tumor Cell-Selective Inhibitor of Mitogen-Activated Protein Kinase Phosphatases Sensitizes Breast Cancer Cells to Lymphokine-Activated Killer Cell Activity.RAS pathway mutations as a predictive biomarker for treatment adaptation in pediatric B-cell precursor acute lymphoblastic leukemia.Translational control of ERK signaling through miRNA/4EHP-directed silencing.Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases.The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex.Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008.Deconstructing Signaling Pathways in Cancer for Optimizing Cancer Combination Therapies.MCP-1-induced ERK/GSK-3β/Snail signaling facilitates the epithelial-mesenchymal transition and promotes the migration of MCF-7 human breast carcinoma cells.Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies.New Approaches to Difficult Drug Targets: The Phosphatase Story
P2860
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P2860
Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Erk Negative Feedback Control ...... Acute Lymphoblastic Leukemia.
@ast
Erk Negative Feedback Control ...... Acute Lymphoblastic Leukemia.
@en
type
label
Erk Negative Feedback Control ...... Acute Lymphoblastic Leukemia.
@ast
Erk Negative Feedback Control ...... Acute Lymphoblastic Leukemia.
@en
prefLabel
Erk Negative Feedback Control ...... Acute Lymphoblastic Leukemia.
@ast
Erk Negative Feedback Control ...... Acute Lymphoblastic Leukemia.
@en
P2093
P2860
P50
P1433
P1476
Erk Negative Feedback Control ...... Acute Lymphoblastic Leukemia.
@en
P2093
Ari Melnick
Cheryl L Willman
Christian Hurtz
Eugene Park
H Phillip Koeffler
Huimin Geng
Kevin R Coombes
Lai N Chan
Lars Klemm
Maike Buchner
P2860
P304
P356
10.1016/J.CCELL.2015.05.008
P577
2015-06-11T00:00:00Z