Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation.
about
Lipid mediators and allergic diseasesPGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2Prostanoid receptor antagonists: development strategies and therapeutic applicationsAccumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthmaThe prostaglandin D₂ receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge.Setipiprant, a selective CRTH2 antagonist, reduces allergen-induced airway responses in allergic asthmatics.Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy.Chitin particles induce size-dependent but carbohydrate-independent innate eosinophiliaLeukotriene E4 activates human Th2 cells for exaggerated proinflammatory cytokine production in response to prostaglandin D2.Mast cells and company.New drugs targeting Th2 lymphocytes in asthma.CRTH2 antagonism significantly ameliorates airway hyperreactivity and downregulates inflammation-induced genes in a mouse model of airway inflammation.The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responsesActivated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung.Two Phase II randomized trials on the CRTh2 antagonist AZD1981 in adults with asthmaTh2 cells as targets for therapeutic intervention in allergic bronchial asthma.Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells.Efficacy and safety of setipiprant in seasonal allergic rhinitis: results from Phase 2 and Phase 3 randomized, double-blind, placebo- and active-referenced studies.DP(2) receptor antagonists in development.Mast cells in allergic asthma and beyond.Novel CRTH2 antagonists: a review of patents from 2006 to 2009.Prostaglandin D₂ and T(H)2 inflammation in the pathogenesis of bronchial asthma.Experimental advances in understanding allergic airway inflammation.Pathogenesis of aspirin-exacerbated respiratory disease and reactions.A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma.Targeting the PGD2/CRTH2/DP1 Signaling Pathway in Asthma and Allergic Disease: Current Status and Future Perspectives.Prostaglandin D2 receptor antagonists in early development as potential therapeutic options for asthma.Current complications and treatment of aspirin-exacerbated respiratory disease.Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma.Novel association between vasoactive intestinal peptide and CRTH2 receptor in recruiting eosinophils: a possible biochemical mechanism for allergic eosinophilic inflammation of the airways.Optimization of the Central Core of Indolinone-Acetic Acid-Based CRTH2 (DP2) Receptor Antagonists.The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation.An epigenome-wide association study of total serum IgE in Hispanic children.Prostaglandins and Their Receptors in Eosinophil Function and As Therapeutic Targets.Viral stimuli trigger exaggerated thymic stromal lymphopoietin expression by chronic obstructive pulmonary disease epithelium: role of endosomal TLR3 and cytosolic RIG-I-like helicases.Hematopoietic prostaglandin D synthase: Linking pathogenic effector CD4(+) T(H)2 cells to proeosinophilic inflammation in patients with gastrointestinal allergic disorders.Regulation of Th9-type pulmonary immune responses: a new role for COX-2.DP2 (CRTh2) antagonism reduces ocular inflammation induced by allergen challenge and respiratory syncytial virus.Interaction between prostaglandin D and chemoattractant receptor-homologous molecule expressed on Th2 cells mediates cytokine production by Th2 lymphocytes in response to activated mast cells.Effects of the cyclin-dependent kinase inhibitor R-roscovitine on eosinophil survival and clearance.
P2860
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P2860
Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Antagonism of the prostaglandi ...... inophilic airway inflammation.
@ast
Antagonism of the prostaglandi ...... inophilic airway inflammation.
@en
type
label
Antagonism of the prostaglandi ...... inophilic airway inflammation.
@ast
Antagonism of the prostaglandi ...... inophilic airway inflammation.
@en
prefLabel
Antagonism of the prostaglandi ...... inophilic airway inflammation.
@ast
Antagonism of the prostaglandi ...... inophilic airway inflammation.
@en
P2093
P2860
P356
P1433
P1476
Antagonism of the prostaglandi ...... inophilic airway inflammation.
@en
P2093
Carl G A Persson
Evi Kostenis
Gunnar Andersson
Lena Uller
Lisa Alenmyr
Magnus Korsgren
Thomas Högberg
P2860
P2888
P356
10.1186/1465-9921-8-16
P577
2007-02-28T00:00:00Z
P5875
P6179
1029913489