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An alternative branch of the nonsense-mediated decay pathway

An alternative branch of the nonsense-mediated decay pathway

http://www.wikidata.org/entity/Q35741768

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DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2 Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact Mechanism and regulation of the nonsense-mediated decay pathway The Supraspliceosome - A Multi-Task Machine for Regulated Pre-mRNA Processing in the Cell Nucleus Nonsense-mediated mRNA decay: inter-individual variability and human disease The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation.Yeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit.Nonsense-mediated mRNA decay in humans at a glance Organizing principles of mammalian nonsense-mediated mRNA decay Mutations in SMG9, Encoding an Essential Component of Nonsense-Mediated Decay Machinery, Cause a Multiple Congenital Anomaly Syndrome in Humans and Mice The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA Contribution of copy number variants involving nonsense-mediated mRNA decay pathway genes to neuro-developmental disorders.Function and pathological implications of exon junction complex factor Y14 The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay.The unfolded protein response affects readthrough of premature termination codons Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay.Frame-disrupting mutations elicit pre-mRNA accumulation independently of frame disruption Stress-sensitive regulation of IFRD1 mRNA decay is mediated by an upstream open reading frame Nonsense-mediated RNA decay regulation by cellular stress: implications for tumorigenesis.Splicing-dependent NMD does not require the EJC in Schizosaccharomyces pombe The code within the code: microRNAs target coding regions.Post-transcriptional regulation of 5-lipoxygenase mRNA expression via alternative splicing and nonsense-mediated mRNA decay A role for nonsense-mediated mRNA decay in plants: pathogen responses are induced in Arabidopsis thaliana NMD mutants.Exon Junction Complexes Show a Distributional Bias toward Alternatively Spliced mRNAs and against mRNAs Coding for Ribosomal Proteins.Nonsense-mediated decay in genetic disease: friend or foe?Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner Transcriptome profiling of UPF3B/NMD-deficient lymphoblastoid cells from patients with various forms of intellectual disability.RNA homeostasis governed by cell type-specific and branched feedback loops acting on NMD.Deep brain stimulation modulates nonsense-mediated RNA decay in Parkinson's patients leukocytes Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells.Method for quantitative analysis of nonsense-mediated mRNA decay at the single cell level Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish.Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay.Widespread use of non-productive alternative splice sites in Saccharomyces cerevisiae shRNA off-target effects in vivo: impaired endogenous siRNA expression and spermatogenic defects.

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P2860

An alternative branch of the nonsense-mediated decay pathway

http://www.wikidata.org/entity/Q35741768

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

An alternative branch of the nonsense-mediated decay pathway

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An alternative branch of the nonsense-mediated decay pathway

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type

label

An alternative branch of the nonsense-mediated decay pathway

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An alternative branch of the nonsense-mediated decay pathway

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prefLabel

An alternative branch of the nonsense-mediated decay pathway

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An alternative branch of the nonsense-mediated decay pathway

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SJ.EMBOJ.7601628

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The EMBO Journal

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An alternative branch of the nonsense-mediated decay pathway

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P2093

James A MacLean

http://www.w3.org/2001/XMLSchema#string

Jayanthi P Gudikote

http://www.w3.org/2001/XMLSchema#string

Lulu Huang

http://www.w3.org/2001/XMLSchema#string

Miles F Wilkinson

http://www.w3.org/2001/XMLSchema#string

Wai-Kin Chan

http://www.w3.org/2001/XMLSchema#string

Yao-Fu Chang

http://www.w3.org/2001/XMLSchema#string

P2860

Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon

Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex

Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay

Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.

Y14 and hUpf3b form an NMD-activating complex

Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay

Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation

Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.

The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

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1820-1830

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6443129

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17363904

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