APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1
about
The recognition of ubiquitinated proteins by the proteasomeRING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitinationFunctions of the 19S complex in proteasomal degradationElectron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdownRegulation of translesion DNA synthesis: Posttranslational modification of lysine residues in key proteinsRegulation of proteasome activity in health and diseaseSynergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.Paradigms of protein degradation by the proteasome.RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complexSubstrate degradation by the proteasome: a single-molecule kinetic analysis.An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitinationGates, Channels, and Switches: Elements of the Proteasome MachineRpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasomeThe Proteasome Distinguishes between Heterotypic and Homotypic Lysine-11-Linked Polyubiquitin Chains.The ubiquitin-proteasome system of Saccharomyces cerevisiae.Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkagesUbiquitin-specific protease 9x deubiquitinates and stabilizes the spinal muscular atrophy protein-survival motor neuronDesign principles of a universal protein degradation machine.An E2 enzyme Ubc11 is required for ubiquitination of Slp1/Cdc20 and spindle checkpoint silencing in fission yeastUSP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites.The Anaphase-Promoting Complex (APC) ubiquitin ligase affects chemosensory behavior in C. elegans.Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid.Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome.Monoubiquitination in proteasomal degradation.Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitinationThe G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20Using the ubiquitin-modified proteome to monitor protein homeostasis function.p97 Promotes a Conserved Mechanism of Helicase Unloading during DNA Cross-Link Repair.Monoubiquitination is critical for ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (Otub1) to suppress UbcH5 enzyme and stabilize p53 protein.The lysine48-based polyubiquitin chain proteasomal signal: not a single child anymore.Panta rhei: the APC/C at steady state.Measuring APC/C-Dependent Ubiquitylation In Vitro.Pushing the Boundaries of Chemical Protein Synthesis: The Case of Ubiquitin Chains and Polyubiquitinated Peptides and Proteins.The fine-tuning of proteolytic pathways in Alzheimer's disease.The increasing complexity of the ubiquitin code.The Spindle Assembly Checkpoint Is Not Essential for Viability of Human Cells with Genetically Lowered APC/C Activity.Upregulated expression of ubiquitin-conjugating enzyme E2Q1 (UBE2Q1) is associated with enhanced cell proliferation and poor prognosis in human hapatocellular carcinoma.UBE2Q1 expression in human colorectal tumors and cell lines.Ubiquitination site preferences in anaphase promoting complex/cyclosome (APC/C) substrates.Monoubiquitination joins polyubiquitination as an esteemed proteasomal targeting signal.
P2860
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P2860
APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
APC/C-mediated multiple monoub ...... gradation signal for cyclin B1
@ast
APC/C-mediated multiple monoub ...... gradation signal for cyclin B1
@en
type
label
APC/C-mediated multiple monoub ...... gradation signal for cyclin B1
@ast
APC/C-mediated multiple monoub ...... gradation signal for cyclin B1
@en
prefLabel
APC/C-mediated multiple monoub ...... gradation signal for cyclin B1
@ast
APC/C-mediated multiple monoub ...... gradation signal for cyclin B1
@en
P2093
P2860
P50
P356
P1433
P1476
APC/C-mediated multiple monoub ...... gradation signal for cyclin B1
@en
P2093
Byung-Hoon Lee
Daniel Finley
Marie Lea Berkowitz
Nathaniel A Hathaway
Nevena V Dimova
P2860
P2888
P304
P356
10.1038/NCB2425
P577
2012-01-29T00:00:00Z