Homeostatically proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model
about
Differentiation of effector CD4 T cell populations (*)Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndromeRag defects and thymic stroma: lessons from animal models.Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndromeExpansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency.Th1-driven immune reconstitution disease in Mycobacterium avium-infected mice.Transient lymphopenia breaks costimulatory blockade-based peripheral tolerance and initiates cardiac allograft rejectionImmunopathogenesis of asymptomatic chronic HIV Infection: the calm before the storm.Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.A four-step model for the IL-6 amplifier, a regulator of chronic inflammations in tissue-specific MHC class II-associated autoimmune diseases.Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects.A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunityLack of iNKT cells in patients with combined immune deficiency due to hypomorphic RAG mutationsQuantitative analysis of T cell homeostatic proliferationMurine models of Omenn syndromeA RAG1 mutation found in Omenn syndrome causes coding flank hypersensitivity: a novel mechanism for antigen receptor repertoire restrictionRapid generation of novel models of RAG1 deficiency by CRISPR/Cas9-induced mutagenesis in murine zygotes.Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation.Breakdown of T cell tolerance and autoimmunity in primary immunodeficiency--lessons learned from monogenic disorders in mice and menRheumatologic and autoimmune manifestations of primary immunodeficiency disorders.Human syndromes of immunodeficiency and dysregulation are characterized by distinct defects in T-cell receptor repertoire development.Genetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics.Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells.Modeling altered T-cell development with induced pluripotent stem cells from patients with RAG1-dependent immune deficiencies.Limited T-cell receptor diversity predisposes to Th2 immunopathology: involvement of Tregs and conventional CD4 T cells.Autoimmunity's collateral damage: Immunodeficiency hints at autoreactivity to cytokines.Variable immune deficiency related to deletion size in chromosome 22q11.2 deletion syndrome.The immune deficiency of chromosome 22q11.2 deletion syndrome.Hypomorphic Rag1 mutations alter the pre-immune repertoire at early stages of lymphoid development.Characterization of an N-Terminal Non-Core Domain of RAG1 Gene Disrupted Syrian Hamster Model Generated by CRISPR Cas9.
P2860
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P2860
Homeostatically proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Homeostatically proliferating ...... an Omenn syndrome murine model
@ast
Homeostatically proliferating ...... an Omenn syndrome murine model
@en
type
label
Homeostatically proliferating ...... an Omenn syndrome murine model
@ast
Homeostatically proliferating ...... an Omenn syndrome murine model
@en
prefLabel
Homeostatically proliferating ...... an Omenn syndrome murine model
@ast
Homeostatically proliferating ...... an Omenn syndrome murine model
@en
P2093
P2860
P356
P1476
Homeostatically proliferating ...... an Omenn syndrome murine model
@en
P2093
Akemi Sakamoto
Brian L Kotzin
Chika Kitabayashi
Katsuhiko Ishihara
Khie Khiong
Marileila Verella-Garcia
Masaaki Murakami
Naoko Ueda
Shin-ichiro Sawa
Stephen J Rozzo
P2860
P304
P356
10.1172/JCI30513
P407
P577
2007-05-01T00:00:00Z