Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.
about
RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptorsNew developments in aminoglycoside therapy and ototoxicityThe unfolding story of megalin (gp330): now recognized as a drug receptorMegalin in acute kidney injury: foe and friendTherapeutic suppression of premature termination codons: mechanisms and clinical considerations (review)Mechanisms of aminoglycoside ototoxicity and targets of hair cell protection.Interference of antibacterial agents with phagocyte functions: immunomodulation or "immuno-fairy tales"?Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention.Intracellular mechanisms of aminoglycoside-induced cytotoxicity.Direct tissue analysis by matrix-assisted laser desorption ionization mass spectrometry: application to kidney biology.Identification of a heparin-binding region of rat thyroglobulin involved in megalin binding.Specific association of megalin and the Na+/H+ exchanger isoform NHE3 in the proximal tubule.Loss of the homotypic fusion and vacuole protein sorting or golgi-associated retrograde protein vesicle tethering complexes results in gentamicin sensitivity in the yeast Saccharomyces cerevisiaeBiomarker discovery by imaging mass spectrometry: transthyretin is a biomarker for gentamicin-induced nephrotoxicity in rat.A megalin-like receptor is involved in protein endocytosis in the midgut of an insect (Bombyx mori, Lepidoptera).Aminoglycosides: nephrotoxicityUptake of polymyxin B into renal cellsMegalin-mediated specific uptake of chitosan/siRNA nanoparticles in mouse kidney proximal tubule epithelial cells enables AQP1 gene silencing.Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule.Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation.The kidney in vitamin B12 and folate homeostasis: characterization of receptors for tubular uptake of vitamins and carrier proteins.Chloride channels in the kidney: lessons learned from knockout animals.Suppression of nonsense mutations as a therapeutic approach to treat genetic diseases.Suppression of CFTR premature termination codons and rescue of CFTR protein and function by the synthetic aminoglycoside NB54RNA as a drug target: the case of aminoglycosides.Calreticulin binds to gentamicin and reduces drug-induced ototoxicity.Emerging drugs for renal failure.Preliminary clinical study of the effect of ascorbic acid on colistin-associated nephrotoxicityMegalin knockout mice as an animal model of low molecular weight proteinuria.Prevention of hepatorenal toxicity with Sonchus asper in gentamicin treated rats.The Role of Megalin in the Transport of Gentamicin Across BeWo Cells, an In Vitro Model of the Human Placenta.Identification of the second cluster of ligand-binding repeats in megalin as a site for receptor-ligand interactionsCharacterization of polymyxin B-induced nephrotoxicity: implications for dosing regimen designNovel polymyxin derivatives carrying only three positive charges are effective antibacterial agents.Biodegradable gentamicin delivery systems for parenteral use for the treatment of intracellular bacterial infections.Organic Cation Transporter 2 Overexpression May Confer an Increased Risk of Gentamicin-Induced Nephrotoxicity.Identification of rat yolk sac target protein of teratogenic antibodies, gp280, as intrinsic factor-cobalamin receptor.Endocytic trafficking of megalin/RAP complexes: dissociation of the complexes in late endosomes.Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis.Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers
P2860
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P2860
Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.
@ast
Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.
@en
type
label
Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.
@ast
Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.
@en
prefLabel
Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.
@ast
Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.
@en
P2093
P2860
P356
P1476
Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.
@en
P2093
Bregengård C
Christensen EI
Gliemann J
Moestrup SK
P2860
P304
P356
10.1172/JCI118176
P407
P577
1995-09-01T00:00:00Z