Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia.
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Novel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1RUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures.Modeling Human Bone Marrow Failure Syndromes Using Pluripotent Stem Cells and Genome EngineeringRUNX1 truncation resulting from a cryptic and novel t(6;21)(q25;q22) chromosome translocation in acute myeloid leukemia: A case reportIntersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression.CBFbeta is critical for AML1-ETO and TEL-AML1 activity.Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles.Runx family genes in a cartilaginous fish, the elephant shark (Callorhinchus milii).PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesisThe ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.Integrative analysis of RUNX1 downstream pathways and target genes.Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes.Syndromic thrombocytopenia and predisposition to acute myelogenous leukemia caused by constitutional microdeletions on chromosome 21q.Array CGH in human leukemia: from somatics to genetics.Chromosome anomalies in bone marrow as primary cause of aplastic or hypoplastic conditions and peripheral cytopenia: disorders due to secondary impairment of RUNX1 and MPL genesImpaired hematopoietic differentiation of RUNX1-mutated induced pluripotent stem cells derived from FPD/AML patients.Two novel RUNX1 mutations in a patient with congenital thrombocytopenia that evolved into a high grade myelodysplastic syndromeRUNX family members are covalently modified and regulated by PIAS1-mediated sumoylationStem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis.Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal.PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex.TdT expression in acute myeloid leukemia with minimal differentiation is associated with distinctive clinicopathological features and better overall survival following stem cell transplantation.Metastatic bone disease: role of transcription factors and future targets.Characterization of the Runx gene family in a jawless vertebrate, the Japanese lamprey (Lethenteron japonicum).RUNX1 repression-independent mechanisms of leukemogenesis by fusion genes CBFB-MYH11 and AML1-ETO (RUNX1-RUNX1T1).Runx transcription factors repress human and murine c-Myc expression in a DNA-binding and C-terminally dependent manner.Functionally deregulated AML1/RUNX1 cooperates with BCR-ABL to induce a blastic phase-like phenotype of chronic myelogenous leukemia in mice.SomInaClust: detection of cancer genes based on somatic mutation patterns of inactivation and clustering.Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2.Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL.Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.The genomic landscape of juvenile myelomonocytic leukemia.Gatekeeper pathways and cellular background in the pathogenesis and therapy of AML.RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity.Pharmacogenetics of alkylator-associated acute myeloid leukemia.RUNX1 mutations in cytogenetically normal acute myeloid leukemia are associated with a poor prognosis and up-regulation of lymphoid genes.Evaluation of the relationship between dietary factors, CagA-positive Helicobacter pylori infection, and RUNX3 promoter hypermethylation in gastric cancer tissueTranscriptional dysregulation during myeloid transformation in AML.CEH-20/Pbx and UNC-62/Meis function upstream of rnt-1/Runx to regulate asymmetric divisions of the C. elegans stem-like seam cells.
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Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia.
@ast
Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia.
@en
type
label
Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia.
@ast
Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia.
@en
prefLabel
Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia.
@ast
Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia.
@en
P2860
P356
P1433
P1476
Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia.
@en
P2093
Motomi Osato
P2860
P2888
P304
P356
10.1038/SJ.ONC.1207779
P407
P577
2004-05-01T00:00:00Z