Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis. - Wikidata - wikimedia - TriplyDB

Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis.

Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis.

http://www.wikidata.org/entity/Q35794336

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Stimulation of c-Myc transcriptional activity by vIRF-3 of Kaposi sarcoma-associated herpesvirus Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exit The Arf-inducing transcription factor Dmp1 encodes a transcriptional activator of amphiregulin, thrombospondin-1, JunB and Egr1 A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth Aurora kinases: novel therapy targets in cancers Myc suppression of Nfkb2 accelerates lymphomagenesis.Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state.p27Kip1 mediates addiction of ovarian cancer cells to MYCC (c-MYC) and their dependence on MYC paralogs.Cks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignancies Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma.Cks overexpression enhances chemotherapeutic efficacy by overriding DNA damage checkpoints.SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27(KIP1) through SKP2 in human leukemia cells.ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma.Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis.Identification and pharmacological inactivation of the MYCN gene network as a therapeutic strategy for neuroblastic tumor cells Skp2 is necessary for Myc-induced keratinocyte proliferation but dispensable for Myc oncogenic activity in the oral epithelium GP130 activation induces myeloma and collaborates with MYC.Androgens as therapy for androgen receptor-positive castration-resistant prostate cancer.Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins NHERF-2 maintains endothelial homeostasis.p27kip1 protein levels reflect a nexus of oncogenic signaling during cell transformation.Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis Tristetraprolin impairs myc-induced lymphoma and abolishes the malignant state Cks1 promotion of S phase entry and proliferation is independent of p27Kip1 suppression The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation TGF-β activates APC through Cdh1 binding for Cks1 and Skp2 proteasomal destruction stabilizing p27kip1 for normal endometrial growth.Cks1 enhances transcription efficiency at the GAL1 locus by linking the Paf1 complex to the 19S proteasome Loss of cks1 homeostasis deregulates cell division cycle.Epstein-Barr virus latent membrane protein 2A enhances MYC-driven cell cycle progression in a mouse model of B lymphoma.Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4) targets expression of cellular IRF4 and the Myc gene to facilitate lytic replication.Cks1: Structure, Emerging Roles and Implications in Multiple Cancers CDK4 deficiency promotes genomic instability and enhances Myc-driven lymphomagenesis.Transcriptomic network support distinct roles of classical and non-classical monocytes in human.MYC-associated and double-hit lymphomas: a review of pathobiology, prognosis, and therapeutic approaches.Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma.Gene expression signature of c-MYC-immortalized human fibroblasts reveals loss of growth inhibitory response to TGFβ.Cks1 proteasomal degradation is induced by inhibiting Hsp90-mediated chaperoning in cancer cells.MYC Modulation around the CDK2/p27/SKP2 Axis Retinoic acid induces REST degradation and neuronal differentiation by modulating the expression of SCF(β-TRCP) in neuroblastoma cells.

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Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis.

http://www.wikidata.org/entity/Q35794336

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Myc targets Cks1 to provoke th ...... iferation and lymphomagenesis.

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Myc targets Cks1 to provoke th ...... iferation and lymphomagenesis.

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type

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Myc targets Cks1 to provoke th ...... iferation and lymphomagenesis.

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Myc targets Cks1 to provoke th ...... iferation and lymphomagenesis.

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Myc targets Cks1 to provoke th ...... iferation and lymphomagenesis.

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Myc targets Cks1 to provoke th ...... iferation and lymphomagenesis.

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SJ.EMBOJ.7601691

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The EMBO Journal

P1476

Myc targets Cks1 to provoke th ...... iferation and lymphomagenesis.

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P2093

Charles Spruck

http://www.w3.org/2001/XMLSchema#string

Chunying Yang

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Frank C Dorsey

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Jennifer B Old

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John L Cleveland

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Jonas A Nilsson

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Kelli Boyd

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Kirsteen H MacLean

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Linda Chung

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Lisa Nilsson

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P2860

The expression of the ubiquitin ligase subunit Cks1 in human breast cancer

Identification of putative c-Myc-responsive genes: characterization of rcl, a novel growth-related gene

Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase

Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.

CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase

The ornithine decarboxylase gene is a transcriptional target of c-Myc

Suppression of tumorigenesis by the p53 target PUMA

c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL

CDK inhibitors: positive and negative regulators of G1-phase progression

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

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2562-2574

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10.1038/SJ.EMBOJ.7601691

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10

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26

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2007-04-26T00:00:00Z

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6365602

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17464290

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1868903

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