K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells - Wikidata - wikimedia - TriplyDB

K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells

K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells

http://www.wikidata.org/entity/Q35804477

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A novel method for detection of phosphorylation in single cells by surface enhanced Raman scattering (SERS) using composite organic-inorganic nanoparticles (COINs)Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment Engineering mouse models with myelodysplastic syndrome human candidate genes; how relevant are they?High-dimensional single-cell cancer biology Oncogenic Kras initiates leukemia in hematopoietic stem cells Phase II study of the oral MEK inhibitor selumetinib in advanced acute myelogenous leukemia: a University of Chicago phase II consortium trial.High-content single-cell drug screening with phosphospecific flow cytometry.Flow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia.p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.Development and application of 'phosphoflow' as a tool for immunomonitoring Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation.Induction of histiocytic sarcoma in mouse skeletal muscle.Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner.Molecular targets for the treatment of juvenile myelomonocytic leukemia.Minor Type IV Collagen α5 Chain Promotes Cancer Progression through Discoidin Domain Receptor-1.A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice.Negative effects of GM-CSF signaling in a murine model of t(8;21)-induced leukemia.mTORC1 is essential for leukemia propagation but not stem cell self-renewal.Signaling profiling at the single-cell level identifies a distinct signaling signature in murine hematopoietic stem cells Targeting oncogenic Ras signaling in hematologic malignancies.Timing of the loss of Pten protein determines disease severity in a mouse model of myeloid malignancy.Inactivating Icmt ameliorates K-RAS-induced myeloproliferative disease.K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors.Notch1 gene mutations target KRAS G12D-expressing CD8+ cells and contribute to their leukemogenic transformation.Targeting the PI3K/Akt pathway in murine MDS/MPN driven by hyperactive Ras.Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines.Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation.Mouse models of human AML accurately predict chemotherapy response Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis Stat5 is critical for the development and maintenance of myeloproliferative neoplasm initiated by Nf1 deficiency Overexpression of Rheb2 enhances mouse hematopoietic progenitor cell growth while impairing stem cell repopulation.Hematopoietic expression of oncogenic BRAF promotes aberrant growth of monocyte-lineage cells resistant to PLX4720.Ras signaling regulates osteoprogenitor cell proliferation and bone formation.Mouse tissues that undergo neoplastic progression after K-Ras activation are distinguished by nuclear translocation of phospho-Erk1/2 and robust tumor suppressor responses.Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells

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K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells

http://www.wikidata.org/entity/Q35804477

description

2006 nî lūn-bûn

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K-RasG12D expression induces h ...... opoietic stem/progenitor cells

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Benjamin S Braun

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Emmanuelle Passegué

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Ernesto Díaz-Flores

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Joehleen A Archard

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Kevin Shannon

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Nikesh Kotecha

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P2860

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

The guanine nucleotide-binding switch in three dimensions

Targeting RAS signalling pathways in cancer therapy

Prognostic factors and scoring systems in chronic myelomonocytic leukemia: a retrospective analysis of 213 patients

Stem cell factor and hematopoiesis

Proteins regulating Ras and its relatives

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

Nf1 and Gmcsf interact in myeloid leukemogenesis

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Jonathan M. Irish

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6608995

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1874575

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