Surrogate light chain expressing human peripheral B cells produce self-reactive antibodies.
about
IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humansResolve, revise, and relax: the 3 Rs of B cell repertoire adjustmentB cell receptor editing in tolerance and autoimmunityUnmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity.Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance.Memory B cell antibodies to HIV-1 gp140 cloned from individuals infected with clade A and B viruses.A minimal model of peptide binding predicts ensemble properties of serum antibodies.B-cell-lineage immunogen design in vaccine development with HIV-1 as a case studyIdentification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodiesProduction of IgG autoantibody requires expression of activation-induced deaminase in early-developing B cells in a mouse model of SLE.Analysis of expressed and non-expressed IGK locus rearrangements in chronic lymphocytic leukemia.Mature B cells class switched to IgD are autoreactive in healthy individualsDedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells.B cell receptor light chain repertoires show signs of selection with differences between groups of healthy individuals and SLE patients.The majority of intestinal IgA+ and IgG+ plasmablasts in the human gut are antigen-specific.Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors.Activation-induced cytidine deaminase (AID) is required for B-cell tolerance in humans.The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humansDifferential regulation of self-reactivity discriminates between IgG+ human circulating memory B cells and bone marrow plasma cells.Autoreactivity in human IgG+ memory B cells.A protective role for innate immunity in systemic lupus erythematosus.Defective B cell tolerance in adenosine deaminase deficiency is corrected by gene therapyCirculating Human CD27-IgA+ Memory B Cells Recognize Bacteria with Polyreactive IgsHuman B-cell ontogeny in humanized NOD/SCID γc(null) mice generates a diverse yet auto/poly- and HIV-1-reactive antibody repertoire.Lentiviral-mediated gene therapy restores B cell tolerance in Wiskott-Aldrich syndrome patients.The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire.Persistent expression of autoantibodies in SLE patients in remission.A checkpoint for autoreactivity in human IgM+ memory B cell developmentCD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance.B-cell tolerance checkpoints in healthy humans and patients with systemic lupus erythematosus.Human autoantibody silencing by immunoglobulin light chainsDefective B cell tolerance checkpoints in systemic lupus erythematosusImpaired early B cell tolerance in patients with rheumatoid arthritis.Bruton's tyrosine kinase is essential for human B cell toleranceEfficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloningMonoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition.Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors.Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte MemoryPolyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligationHuman immunoglobulin selection associated with class switch and possible tolerogenic origins for C delta class-switched B cells.
P2860
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P2860
Surrogate light chain expressing human peripheral B cells produce self-reactive antibodies.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Surrogate light chain expressi ...... duce self-reactive antibodies.
@ast
Surrogate light chain expressi ...... duce self-reactive antibodies.
@en
type
label
Surrogate light chain expressi ...... duce self-reactive antibodies.
@ast
Surrogate light chain expressi ...... duce self-reactive antibodies.
@en
prefLabel
Surrogate light chain expressi ...... duce self-reactive antibodies.
@ast
Surrogate light chain expressi ...... duce self-reactive antibodies.
@en
P2093
P2860
P356
P1476
Surrogate light chain expressi ...... duce self-reactive antibodies.
@en
P2093
Eric Davis
Eric Meffre
Hedda Wardemann
Patrick Wilson
P2860
P304
P356
10.1084/JEM.20031550
P407
P577
2003-12-29T00:00:00Z