Mutational analysis of the herpes simplex virus virion host shutoff protein: evidence that vhs functions in the absence of other viral proteins
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Herpes simplex virus virion host shutoff protein is stimulated by translation initiation factors eIF4B and eIF4HThe virion host shutoff protein (UL41) of herpes simplex virus 1 is an endoribonuclease with a substrate specificity similar to that of RNase AHerpes simplex virus 2 infection impacts stress granule accumulationThe herpes simplex virus type 1 vhs-UL41 gene secures viral replication by temporarily evading apoptotic cellular response to infection: Vhs-UL41 activity might require interactions with elements of cellular mRNA degradation machinery.The herpes simplex virus vhs protein induces endoribonucleolytic cleavage of target RNAs in cell extractsHerpes simplex virus virion host shutoff (vhs) activity alters periocular disease in mice.Site-directed mutagenesis of the virion host shutoff gene (UL41) of herpes simplex virus (HSV): analysis of functional differences between HSV type 1 (HSV-1) and HSV-2 alleles.Picornavirus internal ribosome entry site elements target RNA cleavage events induced by the herpes simplex virus virion host shutoff protein.Herpes simplex virus virion host shutoff protein requires a mammalian factor for efficient in vitro endoribonuclease activity.Role of herpes simplex virus ICP27 in the degradation of mRNA by virion host shutoff RNaseNuclear import of cytoplasmic poly(A) binding protein restricts gene expression via hyperadenylation and nuclear retention of mRNA.Sequential localization of two herpes simplex virus tegument proteins to punctate nuclear dots adjacent to ICP0 domainsVaricella-zoster virus (VZV) ORF17 protein induces RNA cleavage and is critical for replication of VZV at 37 degrees C but not 33 degrees C.mRNA degradation by the virion host shutoff (Vhs) protein of herpes simplex virus: genetic and biochemical evidence that Vhs is a nuclease.A subpopulation of tegument protein vhs localizes to detergent-insoluble lipid rafts in herpes simplex virus-infected cells.The U(L)41 protein of herpes simplex virus 1 degrades RNA by endonucleolytic cleavage in absence of other cellular or viral proteinsPathogenesis of herpes simplex virus type 2 virion host shutoff (vhs) mutants.Herpes simplex virus ICP27 is required for virus-induced stabilization of the ARE-containing IEX-1 mRNA encoded by the human IER3 geneImportin alpha-mediated nuclear import of cytoplasmic poly(A) binding protein occurs as a direct consequence of cytoplasmic mRNA depletionPackaging of the virion host shutoff (Vhs) protein of herpes simplex virus: two forms of the Vhs polypeptide are associated with intranuclear B and C capsids, but only one is associated with enveloped virionsHerpes simplex virus VP16 rescues viral mRNA from destruction by the virion host shutoff functionIdentification and characterization of a small modular domain in the herpes simplex virus host shutoff protein sufficient for interaction with VP16.The virion host shutoff protein of herpes simplex virus type 1: messenger ribonucleolytic activity in vitroAnalysis of conserved domains of UL41 of herpes simplex virus type 1 in virion host shutoff and pathogenesisExpression and function of the equine herpesvirus 1 virion-associated host shutoff homolog.Repression of host RNA polymerase II transcription by herpes simplex virus type 1Inhibition of human immunodeficiency virus replication by the herpes simplex virus virion host shutoff protein.Mutational analysis of the virion host shutoff gene (UL41) of herpes simplex virus (HSV): characterization of HSV type 1 (HSV-1)/HSV-2 chimerasInteraction of herpes simplex virus RNase with VP16 and VP22 is required for the accumulation of the protein but not for accumulation of mRNARoles of nucleic acid substrates and cofactors in the vhs protein activity of pseudorabies virus.Selective ablation of virion host shutoff protein RNase activity attenuates herpes simplex virus 2 in mice.Small interfering RNAs that deplete the cellular translation factor eIF4H impede mRNA degradation by the virion host shutoff protein of herpes simplex virusMode of virus rescue determines the acquisition of VHS mutations in VP22-negative herpes simplex virus 1.Role of the VP16-binding domain of vhs in viral growth, host shutoff activity, and pathogenesis.The amino terminus of the herpes simplex virus 1 protein Vhs mediates membrane association and tegument incorporation.The vhs1 mutant form of herpes simplex virus virion host shutoff protein retains significant internal ribosome entry site-directed RNA cleavage activity.Evidence of a role for nonmuscle myosin II in herpes simplex virus type 1 egress.Herpes simplex virus type 1 protein IE63 affects the nuclear export of virus intron-containing transcripts.The DNase of gammaherpesviruses impairs recognition by virus-specific CD8+ T cells through an additional host shutoff function.Evidence for translational regulation by the herpes simplex virus virion host shutoff protein
P2860
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P2860
Mutational analysis of the herpes simplex virus virion host shutoff protein: evidence that vhs functions in the absence of other viral proteins
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Mutational analysis of the her ...... bsence of other viral proteins
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Mutational analysis of the her ...... bsence of other viral proteins
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type
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Mutational analysis of the her ...... bsence of other viral proteins
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Mutational analysis of the her ...... bsence of other viral proteins
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Mutational analysis of the her ...... bsence of other viral proteins
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Mutational analysis of the her ...... bsence of other viral proteins
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P2093
P2860
P1433
P1476
Mutational analysis of the her ...... bsence of other viral proteins
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P2093
P2860
P304
P407
P577
1995-08-01T00:00:00Z