Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy.
about
Repurposing metformin: an old drug with new tricks in its binding pocketsProtein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fateAutophagy modulation as a target for anticancer drug discoveryMetformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated MacrophagesPotential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseasesIn Vitro Anti-Echinococcal and Metabolic Effects of Metformin Involve Activation of AMP-Activated Protein Kinase in Larval Stages of Echinococcus granulosusBcl-2high mantle cell lymphoma cells are sensitized to acadesine with ABT-199.Comparison of Antidiabetic Medications during the Treatment of Atherosclerosis in T2DM Patients.Metformin impairs growth of endometrial cancer cells via cell cycle arrest and concomitant autophagy and apoptosis.Metformin ameliorates hepatic steatosis and improves the induction of autophagy in HFD‑induced obese mice.Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy.The pro-apoptotic role of autophagy in breast cancerTOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists.Targeting autophagy overcomes Enzalutamide resistance in castration-resistant prostate cancer cells and improves therapeutic response in a xenograft modelThe hepatitis C virus modulates insulin signaling pathway in vitro promoting insulin resistanceAutophagy plays a critical role in ChLym-1-induced cytotoxicity of non-hodgkin's lymphoma cellsGSTT1 deletion is related to polycyclic aromatic hydrocarbons-induced DNA damage and lymphoma progressionTAp73 promotes anabolismMetformin inhibits growth of human glioblastoma cells and enhances therapeutic response(Z)3,4,5,4'-trans-tetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant non-small cell lung cancer via selectively elevating intracellular calcium level.Koschei the immortal and anti-aging drugsAutophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway.Metformin: Midlife maturity, maiden charmProteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches.Metformin selectively affects human glioblastoma tumor-initiating cell viability: A role for metformin-induced inhibition of Akt.Metformin inhibits growth of human non-small cell lung cancer cells via liver kinase B-1-independent activation of adenosine monophosphate-activated protein kinase.Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK.Autophagy in breast cancer and its implications for therapyActivation of autophagy flux by metformin downregulates cellular FLICE-like inhibitory protein and enhances TRAIL- induced apoptosis.Cabazitaxel-induced autophagy via the PI3K/Akt/mTOR pathway contributes to A549 cell death.Metformin targets c-MYC oncogene to prevent prostate cancer.Enhanced anti-tumor activity and cytotoxic effect on cancer stem cell population of metformin-butyrate compared with metformin HCl in breast cancer.Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo.Metformin targets multiple signaling pathways in cancer.Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling.Rhein Inhibits Autophagy in Rat Renal Tubular Cells by Regulation of AMPK/mTOR Signaling.Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration.Metformin promotes apoptosis in hepatocellular carcinoma through the CEBPD-induced autophagy pathway.Autophagy regulates inflammation following oxidative injury in diabetes.Repositioning metformin in cancer: genetics, drug targets, and new ways of delivery.
P2860
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P2860
Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Therapeutic metformin/AMPK act ...... ay and induction of autophagy.
@ast
Therapeutic metformin/AMPK act ...... ay and induction of autophagy.
@en
type
label
Therapeutic metformin/AMPK act ...... ay and induction of autophagy.
@ast
Therapeutic metformin/AMPK act ...... ay and induction of autophagy.
@en
prefLabel
Therapeutic metformin/AMPK act ...... ay and induction of autophagy.
@ast
Therapeutic metformin/AMPK act ...... ay and induction of autophagy.
@en
P2093
P2860
P356
P1476
Therapeutic metformin/AMPK act ...... ay and induction of autophagy.
@en
P2093
P2860
P356
10.1038/CDDIS.2012.13
P577
2012-03-01T00:00:00Z