Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis.
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Zinc-mediated Allosteric Inhibition of Caspase-6Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activationTetra-O-Methyl Nordihydroguaiaretic Acid Broadly Suppresses Cancer Metabolism and Synergistically Induces Strong Anticancer Activity in Combination with Etoposide, Rapamycin and UCN-01Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.Evaluation of cytotoxic and chemotherapeutic properties of boldine in breast cancer using in vitro and in vivo models.Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates.Andrographolide induces apoptosis of C6 glioma cells via the ERK-p53-caspase 7-PARP pathway.Resveratrol inhibits proliferation in human colorectal carcinoma cells by inducing G1/S‑phase cell cycle arrest and apoptosis through caspase/cyclin‑CDK pathways.A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases.Differential effects of HIF-α isoforms on apoptosis in renal carcinoma cell lines.Caspase-7: a critical mediator of optic nerve injury-induced retinal ganglion cell deathConservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosisA tunable, modular approach to fluorescent protease-activated reporters.Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles.Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapyPoly(ADP-ribose) polymerase is a substrate recognized by two metacaspases of Podospora anserina.Phytoestrogen Bakuchiol Exhibits In Vitro and In Vivo Anti-breast Cancer Effects by Inducing S Phase Arrest and ApoptosisReprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.Caspase substrates and inhibitorsTriptolide induces lysosomal-mediated programmed cell death in MCF-7 breast cancer cells.Tannic Acid preferentially targets estrogen receptor-positive breast cancer.Cytotoxicity of Salvia miltiorrhiza Against Multidrug-Resistant Cancer Cells.Differential behaviour of cationic triphenylamine derivatives in fixed and living cells: triggering and imaging cell death.Carbon ion beam triggers both caspase-dependent and caspase-independent pathway of apoptosis in HeLa and status of PARP-1 controls intensity of apoptosis.Anti-tumour activity of phosphoinositide-3-kinase antagonist AEZS 126 in models of triple-negative breast cancer.Caspases rule the intracellular trafficking cartel.Caspases and their substrates.Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degeneration.Ethanolic extract of Thevetia peruviana flowers enhances TNF-α and TRAIL-induced apoptosis of human cervical cancer cells via intrinsic and extrinsic pathways.Caspases play in trafficDual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms.Transcriptome Analysis in Spleen Reveals Differential Regulation of Response to Newcastle Disease Virus in Two Chicken Lines.Multiple mechanisms of zinc-mediated inhibition for the apoptotic caspases -3, -6, -7, & -8.Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1.Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions.Modulation of procaspase-7 self-activation by PEST amino acid residues of the N-terminal prodomain and intersubunit linker.Caspase-9 CARD : core domain interactions require a properly formed active site.Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor
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Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis.
@ast
Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis.
@en
type
label
Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis.
@ast
Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis.
@en
prefLabel
Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis.
@ast
Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis.
@en
P2860
P356
P1476
Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis
@en
P2093
Jean-Bernard Denault
Véronique Blais
P2860
P304
P356
10.1073/PNAS.1200934109
P407
P50
P577
2012-03-26T00:00:00Z