A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade.
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Metal protein attenuating compounds for the treatment of Alzheimer's dementiaMetal protein attenuating compounds for the treatment of Alzheimer's dementiaMetal protein attenuating compounds for the treatment of Alzheimer's diseaseAlzheimer's pathogenesis and its link to the mitochondrionLink between Aluminum and the Pathogenesis of Alzheimer's Disease: The Integration of the Aluminum and Amyloid Cascade HypothesesOral Triphenylmethane Food Dye Analog, Brilliant Blue G, Prevents Neuronal Loss in APPSwDI/NOS2-/- Mouse Model.Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse modelIdentification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosisAlzheimer disease models and human neuropathology: similarities and differencesCombining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Abeta oligomer-induced cytotoxicity.Amyloid-beta peptide binds to microtubule-associated protein 1B (MAP1B).Mechanism of neuronal versus endothelial cell uptake of Alzheimer's disease amyloid beta proteinHH domain of Alzheimer's disease Abeta provides structural basis for neuronal binding in PC12 and mouse cortical/hippocampal neuronsAccumulation of intraneuronal Abeta correlates with ApoE4 genotypeThe nuclear inclusion a (NIa) protease of turnip mosaic virus (TuMV) cleaves amyloid-βAge-associated cerebral atrophy in mouse lemur primatesAltered levels and distribution of amyloid precursor protein and its processing enzymes in Niemann-Pick type C1-deficient mouse brainsNeuron loss in transgenic mouse models of Alzheimer's diseaseCharacterization of the interaction of β-amyloid with transthyretin monomers and tetramers.Decreased proteolytic activity of the mitochondrial amyloid-β degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondriaAmyloid-β peptide binds to cytochrome C oxidase subunit 1.The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated AβClinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity.Age-associated evolution of plasmatic amyloid in mouse lemur primates: relationship with intracellular amyloid deposition.How ionic strength affects the conformational behavior of human and rat beta amyloids--a computational studyMembrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein.The amyloid beta ion channel hypothesis of Alzheimer's disease.Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL/PS1M146L transgenic mice.Bone mineral density, adiposity, and cognitive functionsA reduced astrocyte response to β-amyloid plaques in the ageing brain associates with cognitive impairment.Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseasesIntraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease.In vivo olfactory model of APP-induced neurodegeneration reveals a reversible cell-autonomous function.Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function.Pyroglutamate amyloid-β (Aβ): a hatchet man in Alzheimer diseaseOverexpression of the Insulin-Like Growth Factor II Receptor Increases β-Amyloid Production and Affects Cell Viability.Evaluation of the amyloid beta-GFP fusion protein as a model of amyloid beta peptides-mediated aggregation: a study of DNAJB6 chaperone.Prolonged running, not fluoxetine treatment, increases neurogenesis, but does not alter neuropathology, in the 3xTg mouse model of Alzheimer's diseaseMitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers.APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer's disease.
P2860
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P2860
A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
A modified beta-amyloid hypoth ...... first step of a fatal cascade.
@ast
A modified beta-amyloid hypoth ...... first step of a fatal cascade.
@en
type
label
A modified beta-amyloid hypoth ...... first step of a fatal cascade.
@ast
A modified beta-amyloid hypoth ...... first step of a fatal cascade.
@en
prefLabel
A modified beta-amyloid hypoth ...... first step of a fatal cascade.
@ast
A modified beta-amyloid hypoth ...... first step of a fatal cascade.
@en
P1476
A modified beta-amyloid hypoth ...... first step of a fatal cascade.
@en
P2093
Oliver Wirths
Thomas A Bayer
P304
P356
10.1111/J.1471-4159.2004.02737.X
P407
P577
2004-11-01T00:00:00Z