HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis - Wikidata - wikimedia - TriplyDB

HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis

HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis

http://www.wikidata.org/entity/Q35919080

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The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation How cells switch HIPK2 on and off The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4 Krüppel-like factor 15 activates hepatitis B virus gene expression and replication Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer Role of HIPK2 in kidney fibrosis HIPK2 is a new drug target for anti-fibrosis therapy in kidney disease Cell-context dependent TCF/LEF expression and function: alternative tales of repression, de-repression and activation potentials Homeodomain-Interacting Protein Kinase-2: A Critical Regulator of the DNA Damage Response and the Epigenome A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1.Downregulation of HIPK2 increases resistance of bladder cancer cell to cisplatin by regulating Wip1 Identification of Hipk2 as an essential regulator of white fat development.HIPK2 Overexpression and Its Prognostic Role in Human Papillomavirus-Positive Tonsillar Squamous Cell Carcinoma.Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271.Cutaneous HPV23 E6 prevents p53 phosphorylation through interaction with HIPK2.Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress.Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells.Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2.BRCA1-Dependent Translational Regulation in Breast Cancer Cells.The transcriptional corepressor CtBP: a foe of multiple tumor suppressors.HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma Updates on HIPK2: a resourceful oncosuppressor for clearing cancer Targeting COX-2/PGE(2) pathway in HIPK2 knockdown cancer cells: impact on dendritic cell maturation.Mechanism of Wnt signaling induced down regulation of mrhl long non-coding RNA in mouse spermatogonial cells The implications of cancer stem cells for cancer therapy.Wnt signaling in vertebrate axis specification.HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy The SxxSS motif of T-cell factor-4 isoforms modulates Wnt/β-catenin signal activation in hepatocellular carcinoma cells.Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death.C2ORF40 suppresses breast cancer cell proliferation and invasion through modulating expression of M phase cell cycle genes.HIPK2 modulates p53 activity towards pro-apoptotic transcription.Cancer stem cells: problems for therapy?Wnt signaling through T-cell factor phosphorylation.The proteomics of cancer stem cells: potential clinical applications for innovative research in oncology.Physiological role of β-catenin/TCF signaling in neurons of the adult brain.

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HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis

http://www.wikidata.org/entity/Q35919080

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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HIPK2 represses beta-catenin-m ...... ansion, and skin tumorigenesis

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HIPK2 represses beta-catenin-m ...... ansion, and skin tumorigenesis

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HIPK2 represses beta-catenin-m ...... ansion, and skin tumorigenesis

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HIPK2 represses beta-catenin-m ...... ansion, and skin tumorigenesis

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HIPK2 represses beta-catenin-m ...... ansion, and skin tumorigenesis

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HIPK2 represses beta-catenin-m ...... ansion, and skin tumorigenesis

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Proceedings of the National Academy of Sciences of the United States of America

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HIPK2 represses beta-catenin-m ...... ansion, and skin tumorigenesis

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Allan Balmain

http://www.w3.org/2001/XMLSchema#string

Amy A Tang

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Ettore Appella

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Gene K Ma

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Guangwei Wei

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Jiasheng Zhang

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Shin'ichi Saito

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Stephen Ku

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P2860

Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)

Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

The Wnt signaling pathway in development and disease

A common human skin tumour is caused by activating mutations in beta-catenin

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors

beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer

Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals.

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13040-13045

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104

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6171829

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17666529

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P921

epidermal stem cell homeostasis

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1936219

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