Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma - Wikidata - wikimedia - TriplyDB

Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma

Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma

http://www.wikidata.org/entity/Q35838286

about

Role of HIPK2 in kidney fibrosis HIPK2 is a new drug target for anti-fibrosis therapy in kidney disease Identification of Hipk2 as an essential regulator of white fat development.Verbascoside promotes apoptosis by regulating HIPK2-p53 signaling in human colorectal cancer HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity Updates on HIPK2: a resourceful oncosuppressor for clearing cancer Targeting COX-2/PGE(2) pathway in HIPK2 knockdown cancer cells: impact on dendritic cell maturation.Apoptosis induced by a HIPK2 full-length-specific siRNA is due to off-target effects rather than prevalence of HIPK2-Δe8 isoform.HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death.Response of mouse thymic cells to radiation after transfusion of mesenchymal stem cells.Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies.ShaPINg Cell Fate Upon DNA Damage: Role of Pin1 Isomerase in DNA Damage-Induced Cell Death and Repair.The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression.HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop.Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization.HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation.The Trp53 delta proline (Trp53ΔP) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development Tumor suppressive role for kinases phosphorylating p53 in DNA damage-induced apoptosis

P2860

Q26796620-F75DBB5B-53D6-447C-9D1B-774D55FF9EBE Q26996407-6E0A52A1-D531-473B-8BAB-6D9593925819 Q33665435-9EEB00F3-13D3-4509-91FB-726F3FB9B423 Q34340501-32BDE993-769F-42B7-9B68-BA8D051D38E3 Q35832992-56C95F0C-74E1-418F-AD62-F0B60E0063AB Q36204714-797456B2-A3B1-4F08-B002-8E0E63A476B6 Q36380799-431081F2-7AF7-40E9-8841-A2E773726CE2 Q36738933-17145212-848F-4BAE-A034-D38BAB578385 Q36751275-EAC81033-EFEA-427D-833C-40D14D40A0CE Q36907145-7ACC6021-B2ED-4777-8AE3-5B35C8C57C2D Q37318070-B3110A5E-BC1D-471A-BAD8-CCFD6683DEB1 Q37530501-DFA46DD9-1658-4712-98D4-3A98BE5819B1 Q37746347-C4407EC3-1DAA-4641-B09C-238D512FDEAF Q38225143-0140D285-9926-44A9-8AC9-BAE423D8C0F9 Q38756911-14517EF3-5E69-467E-98A1-3E327B929E90 Q39273658-D5D18736-9C16-46AA-85A6-FACF36A9163C Q41904978-3D0A2964-CCA7-4D54-A65B-82C236241170 Q42020732-313D1494-AFD3-4AD4-B430-6474590BA889 Q42026838-417572F8-F9A3-4603-9FBE-A4A94424AC7A Q58781156-F1CEA6BC-46F7-42C5-B764-38EB4AFE2847

P2860

Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma

http://www.wikidata.org/entity/Q35838286

description

2011 nî lūn-bûn

@nan

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

2011年论文

@zh

2011年论文

@zh-cn

name

Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma

@ast

Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma

@en

type

label

Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma

@ast

Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma

@en

prefLabel

Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma

@ast

Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma

@en

P1433

Q35838286-B90E5E8B-883E-4A98-8391-7EFF11DD6073

P1476

Q35838286-1E258BAD-4982-4432-B161-A4784C604AF1

P2093

Q35838286-0C4FE1F1-C85A-4D86-B886-21856A08DC72

Q35838286-143AECD5-B371-46FD-9F45-B92B0C0FB4A2

Q35838286-21925B7A-1F9A-4433-95B0-31589234D7AA

Q35838286-2DD8528C-0A80-4144-A2F4-4C175390E7E7

Q35838286-3CA97F38-3D58-4C66-99AB-D8AA56B98458

Q35838286-4728ECC5-68C6-4BCF-AC54-E52693F7B830

Q35838286-50557BCD-650D-4C3D-9771-CDDE4E60A1C3

Q35838286-5EFA9AD1-8693-4BC9-BA0E-5811990A2984

Q35838286-64BF5093-3B67-437B-A7F0-14D2788F2D2E

P2860

Q35838286-0256CC38-FDEF-4E4D-92BB-5D9AF3223094

Q35838286-08ABEE5D-3A5F-4661-BF96-74BA0B1A4536

Q35838286-08C93B81-352C-44DC-9CAF-B826F17E4846

Q35838286-2BD443F6-1161-4EF5-B740-377E3E604E89

Q35838286-4B3F3E93-4399-4F34-8594-90B043A008D6

Q35838286-4ED6890A-C81E-4D59-A10B-9BDEC93A93C4

Q35838286-598913EA-F9BF-4C0F-B4D8-C471289DA6C9

Q35838286-84C12642-6554-48F6-897B-CD915B1F0065

Q35838286-A42A6AFF-DF3E-4191-B6EE-F6F7D96C1414

Q35838286-B208CAB9-7280-4925-A7E5-09AB145ED66B

P2888

Q35838286-A2D654F3-8D99-4F6A-ADF7-6190E0250C8A

P304

Q35838286-5AD16C48-64AA-40B5-83F6-7143D9C4E282

P31

Q35838286-CD582079-FDF7-49C3-B8A5-31A3293964BC

P356

Q35838286-974C8968-2379-4E16-83F9-3F6B4CB4E357

P407

Q35838286-654A3FAF-71DA-4009-AE7E-C56F825F3023

P433

Q35838286-D6A0CA38-6C3A-4EF1-BA6D-F34227FEFC69

P478

Q35838286-8E4F2A93-E7C7-4013-ADB9-4C22FE5E3331

P50

Q35838286-45CB0B63-B7B9-4745-944D-4DA02D172BE9

Q35838286-D12BF2F6-1320-4480-AD9D-DB410A207ADA

P577

Q35838286-23CB4847-5C8D-40D6-AB72-4A3D446188BF

P5875

Q35838286-40D2BE37-63BC-4EFA-8798-A1FD815BD2D0

P698

Q35838286-4CD1340E-0B07-4660-A7A6-A24964C1F1A3

P932

Q35838286-62BF3BC3-F99E-40CB-BE3F-992DEBB0CA8E

P356

P1433

P1476

Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma

@en

P2093

A Balmain

http://www.w3.org/2001/XMLSchema#string

A Kumar

http://www.w3.org/2001/XMLSchema#string

D Wu

http://www.w3.org/2001/XMLSchema#string

F G Pelorosso

http://www.w3.org/2001/XMLSchema#string

G Wei

http://www.w3.org/2001/XMLSchema#string

H C Kang

http://www.w3.org/2001/XMLSchema#string

I-J Kim

http://www.w3.org/2001/XMLSchema#string

J Climent

http://www.w3.org/2001/XMLSchema#string

R DelRosario

http://www.w3.org/2001/XMLSchema#string

P2860

HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation

High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth.

Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP.

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.

HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis

Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice.

Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1- and p53-mediated transcription.

P2888

P304

1176-1180

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/ONC.2011.306

http://www.w3.org/2001/XMLSchema#string

P407

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

31

http://www.w3.org/2001/XMLSchema#string

P50

P577

2011-07-25T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51517762

http://www.w3.org/2001/XMLSchema#string

P698

21785465

http://www.w3.org/2001/XMLSchema#string

P932

3307058

http://www.w3.org/2001/XMLSchema#string