Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity. - Wikidata - wikimedia - TriplyDB

Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity.

Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity.

http://www.wikidata.org/entity/Q35966086

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Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and Beyond The required beta cell research for improving treatment of type 2 diabetes Calcineurin inhibition and new-onset diabetes mellitus after transplantation Low-dose interleukin-2 therapy: a driver of an imbalance between immune tolerance and autoimmunity Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging Moderate lifelong overexpression of tuberous sclerosis complex 1 (TSC1) improves health and survival in mice HRES-1/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE.Late-life rapamycin treatment reverses age-related heart dysfunction.Chronic rapamycin treatment causes diabetes in male mice Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists.Rapamycin-induced metabolic defects are reversible in both lean and obese mice Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system.Rapamycin ameliorates nephropathy despite elevating hyperglycemia in a polygenic mouse model of type 2 diabetes, NONcNZO10/LtJ.Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice.Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to.Paradoxical effect of rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo.The combined deletion of S6K1 and Akt2 deteriorates glycemic control in a high-fat diet.Treatment with Tacrolimus and Sirolimus Reveals No Additional Adverse Effects on Human Islets In Vitro Compared to Each Drug Alone but They Are Reduced by Adding Glucocorticoids.Resveratrol potentiates rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet.Can new-onset diabetes after kidney transplant be prevented?Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island.Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.SAD-A kinase controls islet β-cell size and function as a mediator of mTORC1 signaling.Validation of a pretransplant risk score for new-onset diabetes after kidney transplantation.Sirolimus therapy in a child with partially diazoxide-responsive hyperinsulinaemic hypoglycaemia.Facile mechanical shaking method is an improved isolation approach for islet preparation and transplantation.Evidence for rapamycin toxicity in pancreatic β-cells and a review of the underlying molecular mechanisms.Interleukin 2 in the pathogenesis and therapy of type 1 diabetes.Novel strategies for anti-aging drug discovery.mTORC1 pathway mediates beta cell compensatory proliferation in 60 % partial-pancreatectomy mice.Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons.SAD-A and AMPK kinases: the "yin and yang" regulators of mTORC1 signaling in pancreatic β cells.Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells.Engineered hair follicle mesenchymal stem cells overexpressing controlled-release insulin reverse hyperglycemia in mice with type L diabetes.Cardioprotective effects of dietary rapamycin on adult female C57BLKS/J-Leprdb mice.Congenital Hyperinsulinism: Diagnosis and Treatment Update.The Molecular Mechanism of Glucagon-Like Peptide-1 Therapy in Alzheimer's Disease, Based on a Mechanistic Target of Rapamycin Pathway.A small molecule inhibitor of Rheb selectively targets mTORC1 signaling.

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Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity.

http://www.wikidata.org/entity/Q35966086

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An-Chi Tien

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Ashley Rowson-Baldwin

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David Matthew Young

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Hye Young Lee

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Lily Yeh Jan

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Yu Yu Shu

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

Molecular organization of target of rapamycin complex 2.

Electrophysiology of the pancreatic beta-cell

Rapamycin in transplantation: a review of the evidence.

Impaired glucose tolerance as a disease.

TOR and ageing: a complex pathway for a complex process.

Sirolimus is associated with new-onset diabetes in kidney transplant recipients.

Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.

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