Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis. - Wikidata - wikimedia - TriplyDB

Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis.

Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis.

http://www.wikidata.org/entity/Q33898882

about

A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions Multiple roles for the actin cytoskeleton during regulated exocytosis MicroRNAs: a new ray of hope for diabetes mellitus Granuphilin exclusively mediates functional granule docking to the plasma membrane.Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2 Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3 MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells The C2B domain of rabphilin directly interacts with SNAP-25 and regulates the docking step of dense core vesicle exocytosis in PC12 cells Neurexin-1α contributes to insulin-containing secretory granule docking Myosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cells Role of Rab GTPases in membrane traffic and cell physiology Munc-18-1 inhibits phospholipase D activity by direct interaction in an epidermal growth factor-reversible manner.Distinct actions of Rab3 and Rab27 GTPases on late stages of exocytosis of insulin.The interplay between the Rab27A effectors Slp4-a and MyRIP controls hormone-evoked Weibel-Palade body exocytosis.The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane.The Drosophila synaptotagmin-like protein bitesize is required for growth and has mRNA localization sequences within its open reading frame.The role of Rab3a in secretory vesicle docking requires association/dissociation of guanidine phosphates and Munc18-1.Slp4-a/granuphilin-a regulates dense-core vesicle exocytosis in PC12 cells.PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis.ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis.Impaired insulin secretion in transgenic mice over-expressing calpastatin in pancreatic β-cells Structure-function study of mammalian Munc18-1 and C. elegans UNC-18 implicates domain 3b in the regulation of exocytosis.The functions of Munc18-1 in regulated exocytosis.Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site.Survey of Red Fluorescence Proteins as Markers for Secretory Granule Exocytosis Changes in microRNA expression contribute to pancreatic β-cell dysfunction in prediabetic NOD mice On the immense variety and complexity of circumstances conditioning pancreatic β-cell apoptosis in type 1 diabetes APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis.Granuphilin molecularly docks insulin granules to the fusion machinery.Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction.Secretory vesicle docking to the plasma membrane: molecular mechanism and functional significance.Molecular medicine of microRNAs: structure, function and implications for diabetes.Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin.Rab27 effectors, pleiotropic regulators in secretory pathways.The secretion of von Willebrand factor from endothelial cells; an increasingly complicated story.Loss of granuphilin and loss of syntaxin-1A cause differential effects on insulin granule docking and fusion.

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P2860

Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis.

http://www.wikidata.org/entity/Q33898882

description

2002 nî lūn-bûn

@nan

2002 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի հունիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis.

@ast

Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis.

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type

label

Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis.

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Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis.

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prefLabel

Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis.

@ast

Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis.

@en

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Molecular Biology of the Cell

P1476

Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis.

@en

P2093

Christian Frantz

http://www.w3.org/2001/XMLSchema#string

Harald Hirling

http://www.w3.org/2001/XMLSchema#string

Sonia Gattesco

http://www.w3.org/2001/XMLSchema#string

Véronique Perret-Menoud

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P2860

A conformational switch in syntaxin during exocytosis: role of munc18.

Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A

Rab3a binding and secretion-enhancing domains in Rim1 are separate and unique. Studies in adrenal chromaffin cells.

Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion.

t-SNARE activation through transient interaction with a rab-like guanosine triphosphatase.

The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion

Mechanisms of intracellular protein transport

Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

Evolution of the Rab family of small GTP-binding proteins

Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins

P304

1906-1915

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scholarly article

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10.1091/MBC.02-02-0025

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6

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13

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Thierry Coppola

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2002-06-01T00:00:00Z

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11316208

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12058058

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P932

117613

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