Mechanisms of DNA sequence selective alkylation of guanine-N7 positions by nitrogen mustards.
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Development of a cancer DNA phenotype prior to tumor formationTandem mass spectrometry for characterization of covalent adducts of DNA with anticancer therapeuticsSubstituents on quinone methides strongly modulate formation and stability of their nucleophilic adducts.A rationally designed genotoxin that selectively destroys estrogen receptor-positive breast cancer cellsToward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).Oxazaphosphorines: new therapeutic strategies for an old class of drugs.Mechlorethamine-induced DNA-protein cross-linking in human fibrosarcoma (HT1080) cells.Covalent cross-linking of duplex DNA using 4-thio-2'-deoxyuridine as a readily modifiable platform for introduction of reactive functionality into oligonucleotidesDNA methylation by N-methyl-N-nitrosourea: methylation pattern changes in single- and double-stranded DNA, and in DNA with mismatched or bulged guaninesIn vivo and ex vivo magnetic resonance spectroscopy as applied to pharmacokinetic studies with anticancer agents: a review.Nearest neighbor effects on carcinogen binding to guanine runs in DNAInvolvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks.Simple, High-Yield Syntheses of DNA Duplexes Containing Interstrand DNA-DNA Cross-Links Between an N(4) -Aminocytidine Residue and an Abasic SiteDNA damage by anti-cancer agents resolved at the nucleotide level of a single copy gene: evidence for a novel binding site for cisplatin in cells.Properties and reactivity of nucleic acids relevant to epigenomics, transcriptomics, and therapeutics.Deregulation of vital mitotic kinase-phosphatase signaling in hematopoietic stem/progenitor compartment leads to cellular catastrophe in experimental aplastic anemia.The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for irreversible stimulation of DNA cleavage.DNA sequence specificity of antitumor agents. Oncogenes as possible targets for cancer therapy.Thermoresponsive chlorambucil derivatives for tumour targeting.New methods for functionalizing biologically important molecules using triosmium metal clusters.DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards is preserved in intact cells.Intragenomic heterogeneity of DNA damage formation and repair: a review of cellular responses to covalent drug DNA interaction.DNA interstrand crosslinking and sequence selectivity of dimethanesulphonates.S-(2-chloroethyl)glutathione-generated p53 mutation spectra are influenced by differential repair rates more than sites of initial dna damage.Molecular dynamics simulations of chlorambucil/DNA adducts. A structural basis for the 5'-GNC interstrand DNA crosslink formed by nitrogen mustards.99m Tc-labeled NGR-chlorambucil conjugate, 99m Tc-HYNIC-CLB-c(NGR) for targeted chemotherapy and molecular imaging.A Low-Toxicity DNA-Alkylating N-Mustard-Quinoline Conjugate with Preferential Sequence Specificity Exerts Potent Antitumor Activity Against Colorectal Cancer.
P2860
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P2860
Mechanisms of DNA sequence selective alkylation of guanine-N7 positions by nitrogen mustards.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年学术文章
@wuu
1987年学术文章
@zh-cn
1987年学术文章
@zh-hans
1987年学术文章
@zh-my
1987年学术文章
@zh-sg
1987年學術文章
@yue
1987年學術文章
@zh
1987年學術文章
@zh-hant
name
Mechanisms of DNA sequence sel ...... ositions by nitrogen mustards.
@ast
Mechanisms of DNA sequence sel ...... ositions by nitrogen mustards.
@en
type
label
Mechanisms of DNA sequence sel ...... ositions by nitrogen mustards.
@ast
Mechanisms of DNA sequence sel ...... ositions by nitrogen mustards.
@en
prefLabel
Mechanisms of DNA sequence sel ...... ositions by nitrogen mustards.
@ast
Mechanisms of DNA sequence sel ...... ositions by nitrogen mustards.
@en
P2093
P2860
P356
P1476
Mechanisms of DNA sequence sel ...... ositions by nitrogen mustards.
@en
P2093
P2860
P304
10531-10549
P356
10.1093/NAR/15.24.10531
P407
P577
1987-12-01T00:00:00Z