about
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activationAcetylation is indispensable for p53 activationFBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activityMDMX regulation of p53 response to ribosomal stressChemical Variations on the p53 Reactivation ThemeActivation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerizationp53 Acetylation: Regulation and ConsequencesHdmx modulates the outcome of p53 activation in human tumor cellsRegulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damageThe pharmacodynamics of the p53-Mdm2 targeting drug Nutlin: the role of gene-switching noiseProbing Difference in Binding Modes of Inhibitors to MDMX by Molecular Dynamics Simulations and Different Free Energy MethodsModes of p53 regulationp53 ubiquitination: Mdm2 and beyondMDM4 (MDMX) and its Transcript Variants.A Novel Interaction between TFII-I and Mdm2 with a Negative Effect on TFII-I Transcriptional ActivityEngineering a ubiquitin ligase reveals conformational flexibility required for ubiquitin transferProtoporphyrin IX interacts with wild-type p53 protein in vitro and induces cell death of human colon cancer cells in a p53-dependent and -independent manner.MDM2 oligomers: antagonizers of the guardian of the genome.EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma.Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.An invertebrate mdm homolog interacts with p53 and is differentially expressed together with p53 and ras in neoplastic Mytilus trossulus haemocytes.MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional outputThe role of mutant p53 in human cancer.Validation of MdmX as a therapeutic target for reactivating p53 in tumorsDeconstructing nucleotide binding activity of the Mdm2 RING domain.p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors.The MDM2 gene family.Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivoGenomic aberrations of MDM2, MDM4, FGFR1 and FGFR3 are associated with poor outcome in patients with salivary gland cancer.Deacetylation of the DNA-binding domain regulates p53-mediated apoptosisAn RNA-seq protocol to identify mRNA expression changes in mouse diaphyseal bone: applications in mice with bone property altering Lrp5 mutationsNew insights into p53 activationROS and p53 in regulation of UVB-induced HDM2 alternative splicingPolymorphisms of MDM4 and risk of squamous cell carcinoma of the head and neckMdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination.Stochastic modeling and simulation of the p53-MDM2/MDMX loopThe Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity.High levels of Hdmx promote cell growth in a subset of uveal melanomas.Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Mdmx as an essential regulator of p53 activity.
@ast
Mdmx as an essential regulator of p53 activity.
@en
type
label
Mdmx as an essential regulator of p53 activity.
@ast
Mdmx as an essential regulator of p53 activity.
@en
prefLabel
Mdmx as an essential regulator of p53 activity.
@ast
Mdmx as an essential regulator of p53 activity.
@en
P1476
Mdmx as an essential regulator of p53 activity.
@en
P2093
Aart G Jochemsen
P304
P356
10.1016/J.BBRC.2005.03.151
P407
P577
2005-06-01T00:00:00Z