Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: increased neurofilament density in axons without affecting caliber
about
NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growthOverexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunitsRequirement of heavy neurofilament subunit in the development of axons with large calibersAssembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunitSchwann cells of the myelin-forming phenotype express neurofilament protein NF-MDisruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunitsAbsence of the mid-sized neurofilament subunit decreases axonal calibers, levels of light neurofilament (NF-L), and neurofilament contentA novel mouse model of Warburg Micro syndrome reveals roles for RAB18 in eye development and organisation of the neuronal cytoskeletonThe eye lens cytoskeleton.Neurobehavioral characteristics of mice with modified intermediate filament genes.Multiple neuron-specific enhancers in the gene coding for the human neurofilament light chain.Functional analysis of the human neurofilament light chain gene promoter.Ectopic synthesis of epidermal cytokeratins in pancreatic islet cells of transgenic mice interferes with cytoskeletal order and insulin production.Phosphorylation on carboxyl terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: influences on regional neurofilament accumulation, interneurofilament spacing, and axon caliber.Gamma-tubulin can both nucleate microtubule assembly and self-assemble into novel tubular structures in mammalian cells.Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons.Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transportAntagonistic roles of neurofilament subunits NF-H and NF-M against NF-L in shaping dendritic arborization in spinal motor neurons.Neurofilament-dependent radial growth of motor axons and axonal organization of neurofilaments does not require the neurofilament heavy subunit (NF-H) or its phosphorylation.The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate.Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport.A function for keratins and a common thread among different types of epidermolysis bullosa simplex diseasesTransfection of nonmuscle beta- and gamma-actin genes into myoblasts elicits different feedback regulatory responses from endogenous actin genesNeurofilament phosphorylation and their proline-directed kinases in health and disease.Expression of bovine myf5 induces ectopic skeletal muscle formation in transgenic mice.Dynamics of intermediate filaments. Recent progress and unanswered questions.Transgenic models for eye malformations.The regulation of neuron-specific gene expression in the mammalian nervous system.Neurofilament phosphorylation.A role for neurofilaments in the pathogenesis of amyotrophic lateral sclerosis.Alterations of intermediate filaments in various histopathological conditions.Self renewal of embryonic stem cells in the absence of feeder cells and exogenous leukaemia inhibitory factor.Triton-soluble phosphovariants of the high molecular weight neurofilament subunit from NB2a/d1 cells are assembly-competent. Implications for normal and abnormal neurofilament assembly.Desmin/vimentin intermediate filaments are dispensable for many aspects of myogenesis.Deletion of 3'-untranslated region alters the level of mRNA expression of a neurofilament light subunit transgene.Subunit composition of neurofilaments specifies axonal diameter.Neurofilament deficiency in quail caused by nonsense mutation in neurofilament-L gene.The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice.The single neurofilament subunit of the lamprey forms filaments and regulates axonal caliber and neuronal size in vivo.Transgenic analyses reveal developmentally regulated neuron- and muscle-specific elements in the murine neurofilament light chain gene promoter.
P2860
Q24301480-848FCC8B-BDB3-449C-9405-D07D3A347AECQ24657018-20446030-F0E1-4C3E-A110-910A3A02748AQ28510130-782B349E-2497-41AF-9BB1-BC9FFF6EAE2DQ28512783-C23C1D04-B4FB-4141-BC51-6FCAB897AFCEQ28577593-6A112D60-2D02-4ADF-9F54-0C1D7C24F5E0Q28586907-0D51ED87-574D-4B1D-AD7F-12740E356A64Q28587418-B49A60A6-EA17-4772-ABCD-6334D28197AEQ33677248-303E6F7A-BB91-40F1-A7CF-3D8EE7B37451Q33812590-CE138695-3ED4-484D-B510-4659CCA1C2B9Q34279218-C71A8108-3359-469C-85FF-2B31E46E6866Q34368399-21A52DB9-0EF6-4A20-8F70-CEAC57CDF887Q34965461-CE7A0973-8A75-4F87-B05B-3C95B97847C2Q36232435-F03813CB-348E-4BBC-92D7-E61837E35FDFQ36234459-F58AF416-8B15-44DF-8DD4-440629F45DBEQ36235929-46151A70-A771-445C-8674-F1A5F199A31DQ36235989-D26DED86-AA2F-4D9D-9813-359FA5CC0FBCQ36237613-15AE65F8-B926-4335-98FF-402D0B23347CQ36255230-5351B1CF-D352-4A32-AA1A-930F6C34EFFEQ36255486-6AD757D1-4C1C-42A4-8796-A2BDBD52D0C1Q36324735-37D68DFB-2913-48EA-BB06-2DB81B53DDD6Q36325615-C8F9CF35-8270-40A9-96B4-0DBE5F06FC75Q36530599-4100BD7F-9213-4A77-8256-FA5F8EB954CFQ36531356-AB345AC6-B5B8-4C82-80EC-07CE493F53F3Q38070869-96BDAF64-90DF-40AA-AD5C-E2B8E7717C88Q40656139-86F5EDF6-6E84-4F83-BBF6-2FA2D5BEFFE9Q40879798-ED53AF6F-128C-4953-82E5-C75E08C57678Q40942349-555FD357-670F-40E5-BC2A-4A7ABD796EADQ40964411-78058C36-706D-43CD-909A-1CA9B8F20DC6Q41037878-77D889FE-1F3D-4F31-977C-2F3B11E254A4Q41037886-5FC36A52-723C-4C0D-A6CE-DA4788315956Q41037907-31240648-CAD7-46BA-8569-D6C2E619A839Q41138540-1DDA197F-5603-4B02-BA7E-D32BF5A4ADB4Q41473053-0B1C38F8-BE18-44D7-A440-783183EB2F02Q41666693-C923B10A-5E60-4BFE-A901-3455A8001A2DQ41672974-291DEBCE-57D5-472E-BA9D-04F9539E11F8Q41986042-1CFA6B14-F947-420C-8641-70FEB694FE8EQ42194068-BC6D0D02-8ADA-48C7-9B3B-6752FCEF0C18Q43889957-1B3ABBE6-9C7D-43C4-B25A-6967A7EC7ACEQ47233612-0D7E1F84-1597-4914-8E78-947FDF0AC7E8Q48044838-D21960F1-3BA7-4ABB-A4FB-F806DB0CB8F6
P2860
Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: increased neurofilament density in axons without affecting caliber
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Expression of NF-L in both neu ...... xons without affecting caliber
@ast
Expression of NF-L in both neu ...... xons without affecting caliber
@en
type
label
Expression of NF-L in both neu ...... xons without affecting caliber
@ast
Expression of NF-L in both neu ...... xons without affecting caliber
@en
prefLabel
Expression of NF-L in both neu ...... xons without affecting caliber
@ast
Expression of NF-L in both neu ...... xons without affecting caliber
@en
P2093
P2860
P356
P1476
Expression of NF-L in both neu ...... xons without affecting caliber
@en
P2093
D W Cleveland
J D Gearhart
M J Monteiro
P N Hoffman
P2860
P304
P356
10.1083/JCB.111.4.1543
P407
P577
1990-10-01T00:00:00Z