Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I).
about
A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 proteinIdentification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulationUbiquilin functions in autophagy and is degraded by chaperone-mediated autophagyUbiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrinDimerization of ubiquilin is dependent upon the central region of the protein: evidence that the monomer, but not the dimer, is involved in binding presenilinsInteraction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell deathPresenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiencyNeurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutationIdentification of caspases that cleave presenilin-1 and presenilin-2The role of cell cycle-mediated events in Alzheimer's disease.LDL receptor-related protein (LRP) in Alzheimer's disease: towards a unified theory of pathogenesis.Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons.Adenovirus E3-6.7K maintains calcium homeostasis and prevents apoptosis and arachidonic acid release.Neurons bearing presenilins: weapons for defense or suicide?Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling.p53-dependent control of transactivation of the Pen2 promoter by presenilinsExercise and early-onset Alzheimer's disease: theoretical considerations.Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster.Presenilin: RIP and beyond.Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease.Overexpression of N141I PS2 increases γ-secretase activity through up-regulation of Presenilin and Pen-2 in brain mitochondria of NSE/hPS2m transgenic mice.Neuronal cell death in Alzheimer's disease and a neuroprotective factor, humanin.The presenilin-2 loop peptide perturbs intracellular Ca2+ homeostasis and accelerates apoptosis.Capacitative Ca2+ entry is involved in regulating soluble amyloid precursor protein (sAPPalpha) release mediated by muscarinic acetylcholine receptor activation in neuroblastoma SH-SY5Y cells.Mutant nicastrin protein can induce the cytochrome c release and the Bax expression.Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis.Presenilin overexpression arrests cells in the G1 phase of the cell cycle. Arrest potentiated by the Alzheimer's disease PS2(N141I)mutant.Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.Akt activity in presenilin 1 wild-type and mutation transfected human SH-SY5Y neuroblastoma cells after serum deprivation and high glucose stress.Zinc and Alzheimer's Disease: An Update.Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells.
P2860
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P2860
Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I).
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Increased apoptosis arising fr ...... presenilin-2 mutation (N141I).
@ast
Increased apoptosis arising fr ...... presenilin-2 mutation (N141I).
@en
type
label
Increased apoptosis arising fr ...... presenilin-2 mutation (N141I).
@ast
Increased apoptosis arising fr ...... presenilin-2 mutation (N141I).
@en
prefLabel
Increased apoptosis arising fr ...... presenilin-2 mutation (N141I).
@ast
Increased apoptosis arising fr ...... presenilin-2 mutation (N141I).
@en
P2860
P356
P1476
Increased apoptosis arising fr ...... presenilin-2 mutation (N141I).
@en
P2093
M J Monteiro
P2860
P304
P356
10.1083/JCB.139.2.485
P407
P577
1997-10-01T00:00:00Z