Single amino acid substitution altering antigen-binding specificity
about
Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigenIdentification of mutant monoclonal antibodies with increased antigen bindingVariable region framework differences result in decreased or increased affinity of variant anti-digoxin antibodies.Protein evolution on partially correlated landscapes.Nucleotide sequences of five anti-lysozyme monoclonal antibodiesDiversification of specificity after maturation of the antibody response to the HIV gp41 epitope ELDKWA.Protein evolution on rugged landscapes.Somatic diversification of S107 from an antiphosphocholine to an anti-DNA autoantibody is due to a single base change in its heavy chain variable region.Site-directed mutagenesis of an invariant amino acid residue at the variable-diversity segments junction of an antibodySomatic diversification of immunoglobulins.Expression and rearrangement of homologous immunoglobulin VH genes in two mouse strains.Contribution of a single heavy chain residue to specificity of an anti-digoxin monoclonal antibody.Polymorphism in immunoglobulin heavy chains suggesting gene conversion.Galactan-binding antibodies. Diversity and structure of idiotypesEvidence for gene conversion among immunoglobulin heavy chain variable region genesParallel sets of autoantibodies in MRL-lpr/lpr mice. An anti-DNA, anti-SmRNP, anti-gp70 networkPoint mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodies.Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity.Monoclonal antibodies in diagnosis and therapy.Topographic analysis with monoclonal anti-idiotopes: probing the functional anatomy of immunoglobulin variable domains.The molecular origin of anti-DNA antibodies.Strategies to improve usability and preserve accuracy in biological sequence databases.Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.Structural correlates of idiotypy in the arsonate system.From the structure of antibodies to the diversification of the immune response.Derivation and diversification of monoclonal antibodies.Differences in antigen-binding affinity caused by a single amino acid substitution in the variable region of the heavy chain.BK virus terminates tolerance to dsDNA and histone antigens in vivo.Speculation on the role of somatic mutation in the generation of anti-DNA antibodies.Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2α phosphorylation and thereby downregulates IgG secretion despite operational secretory pathway traffic.
P2860
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P2860
Single amino acid substitution altering antigen-binding specificity
description
1982 nî lūn-bûn
@nan
1982年の論文
@ja
1982年学术文章
@wuu
1982年学术文章
@zh-cn
1982年学术文章
@zh-hans
1982年学术文章
@zh-my
1982年学术文章
@zh-sg
1982年學術文章
@yue
1982年學術文章
@zh
1982年學術文章
@zh-hant
name
Single amino acid substitution altering antigen-binding specificity
@ast
Single amino acid substitution altering antigen-binding specificity
@en
type
label
Single amino acid substitution altering antigen-binding specificity
@ast
Single amino acid substitution altering antigen-binding specificity
@en
prefLabel
Single amino acid substitution altering antigen-binding specificity
@ast
Single amino acid substitution altering antigen-binding specificity
@en
P2093
P2860
P356
P1476
Single amino acid substitution altering antigen-binding specificity
@en
P2093
A M Giusti
M D Scharff
S Rudikoff
P2860
P304
P356
10.1073/PNAS.79.6.1979
P407
P577
1982-03-01T00:00:00Z