Point mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodies.
about
Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes.Isolation of germinal centerlike events from human spleen RNA. Somatic hypermutation of a clonally related VH6DJH rearrangement expressed with IgM, IgG, and IgA.Germ line variable regions that match hypermutated sequences in genes encoding murine anti-hapten antibodies.Somatic immunoglobulin hypermutation.Significant structural and functional change of an antigen-binding site by a distant amino acid substitution: proposal of a structural mechanism.Protein evolution on rugged landscapes.On the molecular mechanism of somatic hypermutation of rearranged immunoglobulin genes.Analysis of a T cell receptor gene as a target of the somatic hypermutation mechanism.Parallel evolution of antibody variable regions by somatic processes: consecutive shared somatic alterations in VH genes expressed by independently generated hybridomas apparently acquired by point mutation and selection rather than by gene conversiHeavy-chain class switch does not terminate somatic mutation.Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.Evolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte.Somatic hypermutation of an immunoglobulin mu heavy chain transgene.Defective secretion of an immunoglobulin caused by mutations in the heavy chain complementarity determining region 2.The transcriptional promoter regulates hypermutation of the antibody heavy chain locus.Somatic mutation in constant regions of mouse lambda 1 light chainsEnhancement and destruction of antibody function by somatic mutation: unequal occurrence is controlled by V gene combinatorial associations.The molecular origin of anti-DNA antibodies.Affinity maturation of lymphocyte receptors and positive selection of T cells in the thymus.Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication.Mechanism of antigen-driven somatic hypermutation of rearranged immunoglobulin V(D)J genes in the mouse.Somatic generation of hybrid antibody H chain genes in transgenic mice via interchromosomal gene conversion.Structural analysis of VH4-21 encoded human IgM allo- and autoantibodies against red blood cells.Gene family use and somatic mutation in primary and secondary fluorescein-specific IgM antibody responses.A unifying hypothesis for the molecular mechanism of somatic mutation and gene conversion in rearranged immunoglobulin variable genes.Clonotypic dominance and variable gene elements of pathogenic anti-DNA autoantibodies from a single patient with lupus.
P2860
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P2860
Point mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodies.
description
1988 nî lūn-bûn
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1988年の論文
@ja
1988年学术文章
@wuu
1988年学术文章
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1988年学术文章
@zh-hans
1988年学术文章
@zh-my
1988年学术文章
@zh-sg
1988年學術文章
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1988年學術文章
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1988年學術文章
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name
Point mutations cause the soma ...... iphosphorylcholine antibodies.
@ast
Point mutations cause the soma ...... iphosphorylcholine antibodies.
@en
type
label
Point mutations cause the soma ...... iphosphorylcholine antibodies.
@ast
Point mutations cause the soma ...... iphosphorylcholine antibodies.
@en
prefLabel
Point mutations cause the soma ...... iphosphorylcholine antibodies.
@ast
Point mutations cause the soma ...... iphosphorylcholine antibodies.
@en
P2093
P2860
P356
P1476
Point mutations cause the soma ...... iphosphorylcholine antibodies.
@en
P2093
C Desaymard
M D Scharff
R R Pollock
P2860
P304
P356
10.1084/JEM.167.3.954
P407
P577
1988-03-01T00:00:00Z