Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. - Wikidata - wikimedia - TriplyDB

Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.

Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.

http://www.wikidata.org/entity/Q36294415

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Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects Normal Platelet Integrin Function in Mice Lacking Hydrogen Peroxide-Induced Clone-5 (Hic-5)Novel mouse hemostasis model for real-time determination of bleeding time and hemostatic plug composition.The Structure of an Interdomain Complex That Regulates Talin Activity The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile Kindlin-2 controls bidirectional signaling of integrins Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy.In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling.Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation.A directional switch of integrin signalling and a new anti-thrombotic strategy.Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo.Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance.Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend.Transgenic, inducible RNAi in megakaryocytes and platelets in mice.New insights into the versatile roles of platelet FlnA.Integrin alphaIIbbeta3 activation in Chinese hamster ovary cells and platelets increases clustering rather than affinity New PI(4,5)P2- and membrane proximal integrin-binding motifs in the talin head control beta3-integrin clustering.Recreation of the terminal events in physiological integrin activation.Structural and mechanical functions of integrins.Control of cell adhesion dynamics by Rap1 signaling.Significance of talin in cancer progression and metastasis.Neutrophil adhesion and activation under flow.Analysis of covalent modifications of proteins by oxidized phospholipids using a novel method of peptide enrichment.Integrin αII b tail distal of GFFKR participates in inside-out αII b β3 activation.Chemokine arrest signals to leukocyte integrins trigger bi-directional-occupancy of individual heterodimers by extracellular and cytoplasmic ligands Talins and kindlins: partners in integrin-mediated adhesion.Migfilin and filamin as regulators of integrin activation in endothelial cells and neutrophils.The final steps of integrin activation: the end game Tyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation.Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.

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P2860

Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.

http://www.wikidata.org/entity/Q36294415

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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name

Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.

@ast

Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.

@en

type

label

Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.

@ast

Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.

@en

prefLabel

Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.

@ast

Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.

@en

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Journal of Experimental Medicine

P1476

Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.

@en

P2093

Brian G Petrich

http://www.w3.org/2001/XMLSchema#string

David R Critchley

http://www.w3.org/2001/XMLSchema#string

Feng Ye

http://www.w3.org/2001/XMLSchema#string

Mark H Ginsberg

http://www.w3.org/2001/XMLSchema#string

Patrizia Marchese

http://www.w3.org/2001/XMLSchema#string

Rachel A M Weichert

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Radek C Skoda

http://www.w3.org/2001/XMLSchema#string

Ralph Tiedt

http://www.w3.org/2001/XMLSchema#string

Saskia Spiess

http://www.w3.org/2001/XMLSchema#string

Susan J Monkley

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P2860

Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles

Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion

Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin

Integrins: dynamic scaffolds for adhesion and signaling in platelets

Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.

Talin binding to integrin beta tails: a final common step in integrin activation

Exposure of platelet fibrinogen receptors by ADP and epinephrine.

Hemostasis in the mouse (Mus musculus): a review.

Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival.

The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation.

P304

3103-3111

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10.1084/JEM.20071800

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13

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204

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5761645

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18086863

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2150986

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