Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
about
Structural complex of sterol 14 -demethylase (CYP51) with 14 -methylenecyclopropyl- 7-24, 25-dihydrolanosterolThe role of metabolites in predicting drug-drug interactions: focus on irreversible cytochrome P450 inhibition.Efficient synthesis of mibefradil analogues: an insight into in vitro stability.Ritonavir is the best alternative to ketoconazole as an index inhibitor of cytochrome P450-3A in drug-drug interaction studies.Guide to drug porphyrogenicity prediction and drug prescription in the acute porphyrias.Time-dependent CYP inhibition.In vitro approaches to investigate mechanism-based inactivation of CYP enzymes.The conduct of drug metabolism studies considered good practice (II): in vitro experimentsCytochromes P450: a structure-based summary of biotransformations using representative substrates.Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery.Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2.Application of mechanism-based CYP inhibition for predicting drug-drug interactions.Managing the challenge of chemically reactive metabolites in drug development.Inactivation of Anopheles gambiae Glutathione Transferase ε2 by Epiphyllocoumarin.Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes.Lysine-Targeting Covalent Inhibitors.Mechanisms and Consequences of Drug-Drug Interactions.Inhibitory mechanisms of celastrol on human liver cytochrome P450 1A2, 2C19, 2D6, 2E1 and 3A4.An in vivo assay for elucidating the importance of cytochromes P450 for the ability of a wild mammalian herbivore (Neotoma lepida) to consume toxic plants.Importance of H-abstraction in the final step of nitrosoalkane formation in the mechanism-based inactivation of cytochrome P450 by amine-containing drugsHow is a metabolic intermediate formed in the mechanism-based inactivation of cytochrome P450 by using 1,1-dimethylhydrazine: hydrogen abstraction or nitrogen oxidation?Mechanism of cytochrome P450-3A inhibition by ketoconazole.Analysis of Mechanism-Based Inhibition of CYP 3A4 by a Series of Fluoroquinolone Antibacterial Agents.Mechanism-based inactivation of human cytochrome P450 1A2 and 3A4 isoenzymes by anti-tumor triazoloacridinone C-1305.The mechanism and risk factors of clopidogrel-induced liver injury.Reactive metabolite activation by CYP2C19-mediated rhein hepatotoxicity.Identification and analysis of the reactive metabolites related to the hepatotoxicity of safrole.Improved Predictions of Drug-Drug Interactions Mediated by Time-Dependent Inhibition of CYP3A.
P2860
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P2860
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
@ast
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
@en
type
label
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
@ast
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
@en
prefLabel
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
@ast
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
@en
P2093
P1476
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
@en
P2093
P304
P356
10.2174/138920005774330639
P407
P577
2005-10-01T00:00:00Z