Mechanism of cytochrome P450-3A inhibition by ketoconazole.
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Dual effects of ketoconazole cis-enantiomers on CYP3A4 in human hepatocytes and HepG2 CellsIsoniazid mediates the CYP2B6*6 genotype-dependent interaction between efavirenz and antituberculosis drug therapy through mechanism-based inactivation of CYP2A6.Ritonavir is the best alternative to ketoconazole as an index inhibitor of cytochrome P450-3A in drug-drug interaction studies.Favipiravir inhibits acetaminophen sulfate formation but minimally affects systemic pharmacokinetics of acetaminophen.Effect of blueberry juice on clearance of buspirone and flurbiprofen in human volunteers.Membrane Fluidity Modulates Thermal Stability and Ligand Binding of Cytochrome P4503A4 in Lipid Nanodiscs.In Vitro Biotransformation of Two Human CYP3A Probe Substrates and Their Inhibition during Early Zebrafish Development.In vitro-to-in vivo predictions of drug-drug interactions involving multiple reversible inhibitors.Liver injury associated with ketoconazole: review of the published evidence.Inhibitory Effects of Selected Antituberculosis Drugs on Common Human Hepatic Cytochrome P450 and UDP-glucuronosyltransferase Enzymes.Conserved molecular mechanisms underlying the effects of small molecule xenobiotic chemotherapeutics on cells.In vitro metabolism of testosterone in the horse liver and involvement of equine CYPs 3A89, 3A94 and 3A95.Effect of the CYP3A inhibitors, diltiazem and ketoconazole, on ticagrelor pharmacokinetics in healthy volunteers.A highly selective probe for human cytochrome P450 3A4: isoform selectivity, kinetic characterization and its applications.Drug-drug interaction and doping, part 2: an in vitro study on the effect of non-prohibited drugs on the phase I metabolic profile of stanozolol.Drug-drug interaction and doping, part 1: an in vitro study on the effect of non-prohibited drugs on the phase I metabolic profile of toremifene.Inhibition of human cytochromes P450 in vitro by ritonavir and cobicistat.Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies.Mechanism of in-vitro inhibition of UGT1A1 by paritaprevir.Sunitinib tissue distribution changes after coadministration with ketoconazole in mice.Quantitative prediction of the extent of drug-drug interaction using a physiologically based pharmacokinetic model that includes inhibition of drug metabolism determined in cryopreserved hepatocytes.Unbound liver concentration is the true inhibitor concentration that determines cytochrome P450-mediated drug-drug interactions in rat liver.
P2860
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P2860
Mechanism of cytochrome P450-3A inhibition by ketoconazole.
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2011 nî lūn-bûn
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2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年學術文章
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name
Mechanism of cytochrome P450-3A inhibition by ketoconazole.
@en
Mechanism of cytochrome P450-3A inhibition by ketoconazole.
@nl
type
label
Mechanism of cytochrome P450-3A inhibition by ketoconazole.
@en
Mechanism of cytochrome P450-3A inhibition by ketoconazole.
@nl
prefLabel
Mechanism of cytochrome P450-3A inhibition by ketoconazole.
@en
Mechanism of cytochrome P450-3A inhibition by ketoconazole.
@nl
P2093
P2860
P1476
Mechanism of cytochrome P450-3A inhibition by ketoconazole.
@en
P2093
David J Greenblatt
Jerold S Harmatz
Karthik Venkatakrishnan
Lisa L von Moltke
Michael H Court
Sarah J Parent
Yanli Zhao
P2860
P304
P356
10.1111/J.2042-7158.2010.01202.X
P577
2011-02-01T00:00:00Z