The conduct of drug metabolism studies considered good practice (II): in vitro experiments
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The Effects of Ivermectin on Brugia malayi Females In Vitro: A Transcriptomic ApproachPreclinical Evaluation of the Stability, Safety, and Efficacy of CD101, a Novel EchinocandinRate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat.Pluronic based β-cyclodextrin polyrotaxanes for treatment of Niemann-Pick Type C disease.Pharmacokinetics and pharmacodynamics of Phor21-betaCG(ala), a lytic peptide conjugate.Pharmacokinetics of LJP 993, a tetrameric conjugate of domain 1 of beta2-glycoprotein I for antiphospholipid syndromeRosa26-GFP direct repeat (RaDR-GFP) mice reveal tissue- and age-dependence of homologous recombination in mammals in vivo.Gender dimorphic formation of mouse Mallory-Denk bodies and the role of xenobiotic metabolism and oxidative stressGlobal deregulation of ginseng products may be a safety hazard to warfarin takers: solid evidence of ginseng-warfarin interactionIdentification of In Vitro Metabolites of Amoxicillin in Human Liver Microsomes by LC-ESI/MS.A novel and rapid LC/MS/MS assay for bioanalysis of Azurin p28 in serum and its pharmacokinetics in miceFenretinide metabolism in humans and mice: utilizing pharmacological modulation of its metabolic pathway to increase systemic exposureHigh-Throughput Cytochrome P450 Cocktail Inhibition Assay for Assessing Drug-Drug and Drug-Botanical Interactions.Selection of suitable prodrug candidates for in vivo studies via in vitro studies; the correlation of prodrug stability in between cell culture homogenates and human tissue homogenatesIdentification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum.Maternal Pharmacokinetics and Fetal Disposition of (±)-Citalopram during Mouse Pregnancy.Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites.Effect of biotransformation by liver S9 enzymes on the mutagenicity and cytotoxicity of melanin extracted from Aspergillus nidulans.The importance of drug metabolites synthesis: the case-study of cardiotoxic anticancer drugs.Preclinical pharmacokinetics, metabolism, and toxicity of azurin-p28 (NSC745104) a peptide inhibitor of p53 ubiquitination.In-vivo absorption of pinocembrin-7-O-β-D-glucoside in rats and its in-vitro biotransformation.Rapid structural characterization of in vivo and in vitro metabolites of tinoridine using UHPLC-QTOF-MS/MS and in silico toxicological screening of its metabolites.Stable isotope labeling strategy for curcumin metabolite study in human liver microsomes by liquid chromatography-tandem mass spectrometry.Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome.Anti-diabetic properties of Daphniphyllum macropodum fruit and its active compound.In vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors.Addressing Structural Flexibility at the A-Ring on Salvinorin A: Discovery of a Potent Kappa-Opioid Agonist with Enhanced Metabolic Stability.Drug-drug interaction and doping, part 2: an in vitro study on the effect of non-prohibited drugs on the phase I metabolic profile of stanozolol.LC-MS/MS identification of the principal in vitro and in vivo phase I metabolites of the novel thiosemicarbazone anti-cancer drug, Bp4eT.Combination of hollow-fiber liquid-phase microextraction and capillary electrophoresis for pioglitazone and its main metabolites determination in rat liver microsomal fraction.The in vivo and in vitro phase I metabolism of FYL-67, a novel oxazolidinone antibacterial drug, studied by LC-MS/MS.Study of the in vitro metabolism of TJ0711 using ultra high performance liquid chromatography with quadrupole time-of-flight and ultra fast liquid chromatography with quadrupole linear ion trap mass spectrometry.Characterization of the biotransformation pathways of clomiphene, tamoxifen and toremifene as assessed by LC-MS/(MS) following in vitro and excretion studies.Sex-related pharmacokinetic differences and mechanisms of metapristone (RU486 metabolite).In vitro metabolism study of a novel P38 kinase inhibitor: in silico predictions, structure elucidation using MS/MS-I.Characterizing metabolites and potential metabolic pathways for the novel psychoactive substance methoxetamine.Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters.Metabolic Hydrolysis of Aromatic Amides in Selected Rat, Minipig, and Human In Vitro Systems.Identification and characterization of fluvastatin metabolites in rats by UHPLC/Q-TOF/MS/MS and in silico toxicological screening of the metabolites.Ruthenium-containing P450 inhibitors for dual enzyme inhibition and DNA damage.
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The conduct of drug metabolism studies considered good practice (II): in vitro experiments
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on December 2007
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The conduct of drug metabolism ...... ice (II): in vitro experiments
@en
The conduct of drug metabolism studies considered good practice
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type
label
The conduct of drug metabolism ...... ice (II): in vitro experiments
@en
The conduct of drug metabolism studies considered good practice
@nl
prefLabel
The conduct of drug metabolism ...... ice (II): in vitro experiments
@en
The conduct of drug metabolism studies considered good practice
@nl
P2860
P1476
The conduct of drug metabolism ...... ice (II): in vitro experiments
@en
P2093
Xiaodong Liu
P2860
P304
P356
10.2174/138920007782798207
P407
P50
P577
2007-12-01T00:00:00Z