Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. - Wikidata - wikimedia - TriplyDB

Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

http://www.wikidata.org/entity/Q36301403

about

The ancient drug salicylate directly activates AMP-activated protein kinase AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells AMPK activators: mechanisms of action and physiological activities Regulation of AMP-activated protein kinase by natural and synthetic activators A novel approach to the discovery of anti-tumor pharmaceuticals: searching for activators of liponecrosis AMP-activated protein kinase: a target for drugs both ancient and modern Past strategies and future directions for identifying AMP-activated protein kinase (AMPK) modulators AMPK: a target for drugs and natural products with effects on both diabetes and cancer Structural basis of AMPK regulation by small molecule activators Controls of Nuclear Factor-Kappa B Signaling Activity by 5'-AMP-Activated Protein Kinase Activation With Examples in Human Bladder Cancer Cells The emerging role of AMPK in the regulation of breathing and oxygen supply Dissecting the Dual Role of AMPK in Cancer: From Experimental to Human Studies Evidence of cancer-promoting roles for AMPK and related kinases Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis Activation of AMPK by bitter melon triterpenoids involves CaMKKβ Lipopolysaccharide-induced loss of cultured rat myenteric neurons - role of AMP-activated protein kinase Miltefosine Suppresses Hepatic Steatosis by Activating AMPK Signal Pathway Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug Adenosine Monophosphate-activated Protein Kinase (AMPK) Activators For the Prevention, Treatment and Potential Reversal of Pathological Pain.Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells.Histological evaluation of AMPK signalling in primary breast cancer Glucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase.AMPK activation: a therapeutic target for type 2 diabetes?Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation.The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver.AMP-activated kinase restricts Rift Valley fever virus infection by inhibiting fatty acid synthesis.Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival.Stimulated release of a hyperpolarizing factor (ADHF) from mesenteric artery perivascular adipose tissue: involvement of myocyte BKCa channels and adiponectin.Genistein, resveratrol, and 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside induce cytochrome P450 4F2 expression through an AMP-activated protein kinase-dependent pathway.C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.AMP-activated protein kinase suppresses matrix metalloproteinase-9 expression in mouse embryonic fibroblasts.Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice.Identification of a novel AMPK-PEA15 axis in the anoikis-resistant growth of mammary cells.Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK Metabolic alterations and targeted therapies in prostate cancer.Elevated NF-κB activation is conserved in human myocytes cultured from obese type 2 diabetic patients and attenuated by AMP-activated protein kinase Phosphorylation of the voltage-gated potassium channel Kv2.1 by AMP-activated protein kinase regulates membrane excitability

P2860

Q24630758-9D869E2C-999A-4FE6-9DEC-2748DCFFA826 Q24657352-53EA823E-568A-4171-BA3E-AF267CC9FE98 Q26749158-07DF3D46-6893-485C-8FA1-F9DFC08A6CB9 Q26767334-8CA69C29-54DB-4CCD-915F-A0377ACA9CD6 Q26774351-DCDF00C3-97BC-4776-92A7-0E72BA19F100 Q26864424-3FC4F2EB-FEC2-40BC-BE07-FD0EB7E958ED Q26864679-B4208A72-AAC8-4742-9CDC-195E0DE0C7D8 Q27002908-371B77FD-1C9D-4D8D-96F5-E7B1A6EDAC78 Q27680957-2DA3B8B2-C4C9-42DE-BC61-1FAE4BDCE714 Q28071960-5177DB7E-4CC2-42E3-9AAB-A8CE13898BDF Q28072485-A3A37485-4B66-442F-9034-824051562692 Q28081491-EF9575CC-4BF9-4D71-815D-22E55C429B2E Q28083964-190E1299-F5F2-4B23-B4C9-3B2299706DDE Q28254513-63430EBE-18A2-443B-B629-1B450D4672AD Q28486994-DECE09FA-7795-4831-91B3-98FD7A03B5CB Q28542433-9B4759DA-D250-4726-9024-2A407ED2D7A9 Q28554383-192F107D-C671-4636-921C-8611FE9B2597 Q28569249-0BACC3D0-73FB-4AB9-844F-26BBFABB3B8F Q28829020-5A27D0C5-AF24-4A20-ABEC-F09835BD1A55 Q30383901-92449FCF-AD13-4012-8A23-7289361B884A Q33322641-36EDBB61-DF58-4EDB-BB73-67813A195C0E Q33499119-0E1EA4C2-E44D-42A0-9C2F-6669043C7CDA Q33594309-73CD0CDB-8AEE-4C50-A6E5-901751F1A327 Q33824564-A904C64D-CA9A-4BEB-8E05-D823E5D43DCF Q33922223-F015A747-6406-4E8F-ADB5-1DA2D07A8116 Q33968008-621AC1C5-57A8-4B85-A8BC-8C4E45331326 Q34008450-46CF5582-1274-4F0A-8567-B69A213B7D42 Q34086454-80180395-D250-4111-8578-6BE1E40D1B16 Q34244912-4D741176-1042-4E56-ADE8-D36711E8D785 Q34502017-92A562FC-71C1-46C6-8F19-35A68220283B Q34649302-2461A95C-4C0B-4154-9F9E-103CA8AC84CB Q34715847-BB1EB8C8-5526-4FDE-A7B7-376A8F18C89A Q34852643-E177A19A-D274-4315-BEA1-FD69DE1A20EC Q34963339-D265AEB1-1F1F-4367-871F-D7DCB3F54920 Q34973185-97014E83-E0B1-4AC0-A598-18DF0DB9551A Q35000816-C7A136FE-BEDC-4EBA-94B8-50F5AB235A3E Q35116609-8EDD4115-98D6-417C-A61C-EC0B8257953C Q35401667-B04A551B-7289-4B3D-8E8E-A0490E48931D Q35405108-C4C3A183-9485-465D-BC40-43A7B07AE153 Q35518005-57E55534-D4B8-42CD-B043-E89E8728BD38

P2860

Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

http://www.wikidata.org/entity/Q36301403

description

2007 nî lūn-bûn

@nan

2007年の論文

@ja

2007年学术文章

@wuu

2007年学术文章

@zh-cn

2007年学术文章

@zh-hans

2007年学术文章

@zh-my

2007年学术文章

@zh-sg

2007年學術文章

@yue

2007年學術文章

@zh

2007年學術文章

@zh-hant

name

Mechanism of action of A-76966 ...... AMP-activated protein kinase.

@ast

Mechanism of action of A-76966 ...... AMP-activated protein kinase.

@en

type

label

Mechanism of action of A-76966 ...... AMP-activated protein kinase.

@ast

Mechanism of action of A-76966 ...... AMP-activated protein kinase.

@en

prefLabel

Mechanism of action of A-76966 ...... AMP-activated protein kinase.

@ast

Mechanism of action of A-76966 ...... AMP-activated protein kinase.

@en

P1433

Q36301403-5DB32605-7ED6-400B-8F5A-EA9BAC98CC87

P1476

Q36301403-55879C72-20FB-43FC-934B-50E3F44BAB42

P2093

Q36301403-089AFD39-D4D2-4016-8286-C5454D037DDB

Q36301403-32FE1743-696A-41AA-B6F3-6B75FE2F9D4D

Q36301403-44FF887F-54B8-471C-BF6F-BC47EFFC2B5D

Q36301403-4C16DB2B-0B2A-43CD-8E4D-8C72DC26DF4E

Q36301403-5DDB2B73-1D4C-4A10-9F38-F0EDAE76359C

Q36301403-8FB3B66D-2444-4DAA-A4AE-FD83BFB016B3

P2860

Q36301403-04A9D268-188E-4B59-8210-F5BFA4F26256

Q36301403-04D4EAE1-670C-4FB3-BC43-60599899C506

Q36301403-088B7D9C-35BC-4254-B621-5E2D9DF7D4A3

Q36301403-0BD9A539-DEF0-4C6C-8EA9-539B0052A825

Q36301403-0D1D3D94-9BA8-4B16-B867-8896675FCC8F

Q36301403-0F6348E9-3F20-4026-875D-2FECA48E535B

Q36301403-13792425-140C-4760-8B87-A1364DA80A40

Q36301403-281B6FF5-0E5C-4FCF-B971-9AD2151B3D54

Q36301403-2AA4AC12-81CA-4690-B13D-296C39E4D13B

Q36301403-2E335BEE-E97B-4591-9993-FB020C121D52

P304

Q36301403-3EC28E07-6162-4932-AAAD-F592597DD15C

P31

Q36301403-13CCDC83-718E-4BB3-AD5C-97CDB6E30AD6

P356

Q36301403-6C660F3E-726F-45F5-AB01-8905C7F6EE87

P407

Q36301403-3A4EF38B-E63D-4798-9EEE-14F89223B219

P433

Q36301403-66A2BB53-D2DD-4629-A1B6-51EAA8AFC9D6

P478

Q36301403-ABCB5272-AB26-46B1-B2AC-200C06CF0C8D

P50

Q36301403-61B08C75-126E-4895-981A-DEC5061D76EE

Q36301403-756D9F6A-71B4-4FDE-8FCB-890CF30690CF

Q36301403-D981BE30-1CC5-4212-A65D-8D5913179D37

P577

Q36301403-704D9A9E-CF37-4304-B824-C8EA87A6AC4F

P5875

Q36301403-482E72E2-FE10-406B-840A-35AD71E090E9

P698

Q36301403-1D45A88A-C6D0-4BAE-A7C9-4527A8C913F5

P932

Q36301403-68855D85-DBDD-4BC3-A357-E915689BFC10

P356

P1433

Journal of Biological Chemistry

P1476

Mechanism of action of A-76966 ...... f AMP-activated protein kinase

@en

P2093

Andrew McBride

http://www.w3.org/2001/XMLSchema#string

Fiona A Ross

http://www.w3.org/2001/XMLSchema#string

Kei Sakamoto

http://www.w3.org/2001/XMLSchema#string

Natalia Shpiro

http://www.w3.org/2001/XMLSchema#string

Olga Göransson

http://www.w3.org/2001/XMLSchema#string

Simon A Hawley

http://www.w3.org/2001/XMLSchema#string

P2860

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

Role of AMP-activated protein kinase in mechanism of metformin action

Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation.

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

The AMP-activated protein kinase cascade--a unifying system for energy control

Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes

Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

P304

32549-32560

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M706536200

http://www.w3.org/2001/XMLSchema#string

P407

P433

45

http://www.w3.org/2001/XMLSchema#string

P478

282

http://www.w3.org/2001/XMLSchema#string

P50

David Grahame Hardie

P577

2007-09-12T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

5985968

http://www.w3.org/2001/XMLSchema#string

P698

17855357

http://www.w3.org/2001/XMLSchema#string

P932

2156105

http://www.w3.org/2001/XMLSchema#string