Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP
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SLAM/SLAM interactions inhibit CD40-induced production of inflammatory cytokines in monocyte-derived dendritic cellsThe X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activationSelective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative diseaseGerminal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)Evidence of a large-scale functional organization of mammalian chromosomesInduction of Epitope-Specific Neutralizing Antibodies against West Nile VirusA spectrum of mutations in SH2D1A that causes X-linked lymphoproliferative disease and other Epstein-Barr virus-associated illnessesAssociation between SAP and FynT: Inducible SH3 domain-mediated interaction controlled by engagement of the SLAM receptorExpansion of murine gammaherpesvirus latently infected B cells requires T follicular help.Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84.Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells.Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance.Innate PLZF+CD4+ αβ T cells develop and expand in the absence of Itk.Antigen-specific responses and ANA production in B6.Sle1b mice: a role for SAPRequirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient miceDefective B cell responses in the absence of SH2D1AA novel ICOS-independent, but CD28- and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine.Development of innate CD4+ and CD8+ T cells in Itk-deficient mice is regulated by distinct pathwaysThe power and the promise of restimulation-induced cell death in human immune diseases.Delays and diversions mark the development of B cell responses to Borrelia burgdorferi infection.Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1.X-linked lymphoproliferative disease: clinical, diagnostic and molecular perspective.Adaptors as central mediators of signal transduction in immune cells.Molecular and immunological basis of X-linked lymphoproliferative disease.B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance.Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cellsSLAM Family Receptors Regulate Immunity with and without SAP-related AdaptorsCharacterization of Ly108 in the thymus: evidence for distinct properties of a novel form of Ly108Positive and negative regulation of cellular immune responses in physiologic conditions and diseasesMolecular and cellular pathogenesis of X-linked lymphoproliferative disease.CRISPR-Mediated Slamf1Δ/Δ Slamf5Δ/Δ Slamf6Δ/Δ Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell DefectsCRISPR-Mediated Triple Knockout of SLAMF1, SLAMF5 and SLAMF6 Supports Positive Signaling Roles in NKT Cell Development.Molecular mechanisms in genetically defined autoinflammatory diseases: disorders of amplified danger signaling.Neutralization of IFNgamma defeats haemophagocytosis in LCMV-infected perforin- and Rab27a-deficient micePerforin and lymphohistiocytic proliferative disorders.Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection.Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis.Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation.Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation.
P2860
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P2860
Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP
description
2001 nî lūn-bûn
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2001年の論文
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2001年学术文章
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2001年学术文章
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2001年学术文章
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2001年学术文章
@zh-my
2001年学术文章
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name
Altered lymphocyte responses a ...... e disease gene SH2D1A/DSHP/SAP
@ast
Altered lymphocyte responses a ...... e disease gene SH2D1A/DSHP/SAP
@en
type
label
Altered lymphocyte responses a ...... e disease gene SH2D1A/DSHP/SAP
@ast
Altered lymphocyte responses a ...... e disease gene SH2D1A/DSHP/SAP
@en
prefLabel
Altered lymphocyte responses a ...... e disease gene SH2D1A/DSHP/SAP
@ast
Altered lymphocyte responses a ...... e disease gene SH2D1A/DSHP/SAP
@en
P2093
P2860
P356
P1476
Altered lymphocyte responses a ...... e disease gene SH2D1A/DSHP/SAP
@en
P2093
C S Duckett
L A Mijares
P L Schwartzberg
P2860
P304
P356
10.1073/PNAS.131193098
P407
P577
2001-06-12T00:00:00Z