Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity - Wikidata - wikimedia - TriplyDB

Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

http://www.wikidata.org/entity/Q36320596

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Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease Astrocytes As the Main Players in Primary Degenerative Disorders of the Human Central Nervous System Chronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence?Induced pluripotent stem cells for modeling neurological disorders New Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia Signaling The choreography of neuroinflammation in Huntington's disease Huntington's disease: the past, present, and future search for disease modifiers.Astrocytes conspire with neurons during progression of neurological disease Mouse models of polyglutamine diseases: review and data table. Part I Astrocytes: the missing link in neurologic disease?Current approaches to enhance glutamate transporter function and expression Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease model Targeted ablation of oligodendrocytes triggers axonal damage Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons The ubiquitin proteasome system in glia and its role in neurodegenerative diseases Upregulation of glutamate transporter GLT-1 by mTOR-Akt-NF-кB cascade in astrocytic oxygen-glucose deprivation Molecular Imaging Markers to Track Huntington’s Disease Pathology Human glia can both induce and rescue aspects of disease phenotype in Huntington disease.R6/2 Huntington's disease mice develop early and progressive abnormal brain metabolism and seizures.N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms.Decreased expression of GLT-1 in the R6/2 model of Huntington's disease does not worsen disease progression.Seeking brain biomarkers for preventive therapy in Huntington disease.Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice Microglial Activation in the Pathogenesis of Huntington's Disease.Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in cultured astrocytes.Transplantation of induced pluripotent stem cells improves functional recovery in Huntington's disease rat model.In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects.Human mesenchymal stem cells prolong survival and ameliorate motor deficit through trophic support in Huntington's disease mouse models.Transgenic rat model of Huntington's disease: a histopathological study and correlations with neurodegenerative process in the brain of HD patients.Altered manganese homeostasis and manganese toxicity in a Huntington's disease striatal cell model are not explained by defects in the iron transport system.Impaired brain energy metabolism in the BACHD mouse model of Huntington's disease: critical role of astrocyte-neuron interactions.Lack of interleukin-1 type 1 receptor enhances the accumulation of mutant huntingtin in the striatum and exacerbates the neurological phenotypes of Huntington's disease mice.Protection by glia-conditioned medium in a cell model of Huntington disease Early retinal function deficit without prominent morphological changes in the R6/2 mouse model of Huntington's disease.Animal models of Huntington's disease.Autophagy, inflammation and neurodegenerative disease.

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P2860

Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

http://www.wikidata.org/entity/Q36320596

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2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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name

Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

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Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

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type

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Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

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Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

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prefLabel

Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

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Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

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Journal of Cell Biology

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Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

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Chuan-En Wang

http://www.w3.org/2001/XMLSchema#string

Ji-Yeon Shin

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Shi-Hua Li

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Xiao-Jiang Li

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Zhao-Xue Yu

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Zhi-Hui Fang

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P2860

Interaction of Huntington disease protein with transcriptional activator Sp1

A simplified system for generating recombinant adenoviruses

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

Neurological abnormalities in a knock-in mouse model of Huntington's disease

Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

Selective blockade of astrocytic glutamate transporter GLT-1 with dihydrokainate prevents neuronal death during ouabain treatment of astrocyte/neuron cocultures.

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.

Glutamate transporters in neurologic disease.

Insights into glutamate transport regulation in human astrocytes: cloning of the promoter for excitatory amino acid transporter 2 (EAAT2).

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