Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity
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Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicityGlial cells as intrinsic components of non-cell-autonomous neurodegenerative diseaseAstrocytes As the Main Players in Primary Degenerative Disorders of the Human Central Nervous SystemChronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence?Induced pluripotent stem cells for modeling neurological disordersNew Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia SignalingThe choreography of neuroinflammation in Huntington's diseaseHuntington's disease: the past, present, and future search for disease modifiers.Astrocytes conspire with neurons during progression of neurological diseaseMouse models of polyglutamine diseases: review and data table. Part IAstrocytes: the missing link in neurologic disease?Current approaches to enhance glutamate transporter function and expressionMutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytesHigh-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease modelTargeted ablation of oligodendrocytes triggers axonal damageAstrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neuronsThe ubiquitin proteasome system in glia and its role in neurodegenerative diseasesUpregulation of glutamate transporter GLT-1 by mTOR-Akt-NF-кB cascade in astrocytic oxygen-glucose deprivationMolecular Imaging Markers to Track Huntington’s Disease PathologyHuman glia can both induce and rescue aspects of disease phenotype in Huntington disease.R6/2 Huntington's disease mice develop early and progressive abnormal brain metabolism and seizures.N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms.Decreased expression of GLT-1 in the R6/2 model of Huntington's disease does not worsen disease progression.Seeking brain biomarkers for preventive therapy in Huntington disease.Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model miceMutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease miceMicroglial Activation in the Pathogenesis of Huntington's Disease.Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in cultured astrocytes.Transplantation of induced pluripotent stem cells improves functional recovery in Huntington's disease rat model.In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects.Human mesenchymal stem cells prolong survival and ameliorate motor deficit through trophic support in Huntington's disease mouse models.Transgenic rat model of Huntington's disease: a histopathological study and correlations with neurodegenerative process in the brain of HD patients.Altered manganese homeostasis and manganese toxicity in a Huntington's disease striatal cell model are not explained by defects in the iron transport system.Impaired brain energy metabolism in the BACHD mouse model of Huntington's disease: critical role of astrocyte-neuron interactions.Lack of interleukin-1 type 1 receptor enhances the accumulation of mutant huntingtin in the striatum and exacerbates the neurological phenotypes of Huntington's disease mice.Protection by glia-conditioned medium in a cell model of Huntington diseaseEarly retinal function deficit without prominent morphological changes in the R6/2 mouse model of Huntington's disease.Animal models of Huntington's disease.Autophagy, inflammation and neurodegenerative disease.
P2860
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P2860
Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity
@ast
Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity
@en
type
label
Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity
@ast
Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity
@en
prefLabel
Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity
@ast
Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity
@en
P2093
P2860
P356
P1476
Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity
@en
P2093
Chuan-En Wang
Ji-Yeon Shin
Shi-Hua Li
Xiao-Jiang Li
Zhao-Xue Yu
Zhi-Hui Fang
P2860
P304
P356
10.1083/JCB.200508072
P407
P577
2005-12-01T00:00:00Z