Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1
about
Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repairDVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocksRNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sitesThe dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damageOrchestration of the DNA-damage response by the RNF8 ubiquitin ligaseStructural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repairClaspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activationImpact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaksA viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responsesSpatial organization of the mammalian genome surveillance machinery in response to DNA strand breaksAberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing geneDistinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesisHistone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaksMMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sitesA mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpointMass Spectrometric Analysis of Lysine Ubiquitylation Reveals Promiscuity at Site LevelBLM helicase-dependent and -independent roles of 53BP1 during replication stress-mediated homologous recombination.DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression.Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C.Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications.Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndromeThe intrinsic antiviral defense to incoming HSV-1 genomes includes specific DNA repair proteins and is counteracted by the viral protein ICP0.The ups and downs of p53: understanding protein dynamics in single cellsDevelopment and validation of 'AutoRIF': software for the automated analysis of radiation-induced foci.NMR metabolomic profiling reveals new roles of SUMOylation in DNA damage responseRecruitment and retention dynamics of RECQL5 at DNA double strand break sites.Persistent DNA damage after high dose in vivo gamma exposure of minipig skin.Recruitment kinetics of DNA repair proteins Mdc1 and Rad52 but not 53BP1 depend on damage complexity.53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.DNA repair kinetics in SCID mice Sertoli cells and DNA-PKcs-deficient mouse embryonic fibroblasts.Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.Spatiotemporal dynamics of early DNA damage response proteins on complex DNA lesions.BLM helicase stimulates the ATPase and chromatin-remodeling activities of RAD54.Highlighting the DNA damage response with ultrashort laser pulses in the near infrared and kinetic modeling.The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks.Reduction of hRNase H2 activity in Aicardi-Goutières syndrome cells leads to replication stress and genome instabilityThe p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold.RAD18 activates the G2/M checkpoint through DNA damage signaling to maintain genome integrity after ionizing radiation exposure.Tying the loose ends together in DNA double strand break repair with 53BP1.
P2860
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P2860
Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Dynamic assembly and sustained ...... e are controlled by Mdc1/NFBD1
@ast
Dynamic assembly and sustained ...... e are controlled by Mdc1/NFBD1
@en
type
label
Dynamic assembly and sustained ...... e are controlled by Mdc1/NFBD1
@ast
Dynamic assembly and sustained ...... e are controlled by Mdc1/NFBD1
@en
prefLabel
Dynamic assembly and sustained ...... e are controlled by Mdc1/NFBD1
@ast
Dynamic assembly and sustained ...... e are controlled by Mdc1/NFBD1
@en
P2860
P50
P356
P1476
Dynamic assembly and sustained ...... e are controlled by Mdc1/NFBD1
@en
P2093
Fredrik Melander
P2860
P304
P356
10.1083/JCB.200503043
P407
P577
2005-07-11T00:00:00Z