Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D - Wikidata - wikimedia - TriplyDB

Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

http://www.wikidata.org/entity/Q36326949

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Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway Targeting protein serine/threonine phosphatases for drug development Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy Medulloblastoma-biology and microenvironment: a review WIP1 phosphatase as pharmacological target in cancer therapy.Wild-type p53-induced Phosphatase 1 Deficiency Exacerbates Myocardial Infarction-induced Ischemic Injury.Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response Mutation and expression analysis in medulloblastoma yields prognostic variants and a putative mechanism of disease for i17q tumors.PPM1D silencing by RNA interference inhibits the proliferation of lung cancer cells Protein phosphatase magnesium-dependent 1δ (PPM1D) mRNA expression is a prognosis marker for hepatocellular carcinoma CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth WIP1 phosphatase as a potential therapeutic target in neuroblastoma Viewing serine/threonine protein phosphatases through the eyes of drug designers Absence of Wip1 partially rescues Atm deficiency phenotypes in mice.WIP1 stimulates migration and invasion of salivary adenoid cystic carcinoma by inducing MMP-9 and VEGF-C.A suppressive role of ionizing radiation-responsive miR-29c in the development of liver carcinoma via targeting WIP1 HDM2 promotes WIP1-mediated medulloblastoma growth.Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System Molecular determinants of ovarian cancer chemoresistance: new insights into an old conundrum Regulation of the Wip1 phosphatase and its effects on the stress response.The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants Wip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesis The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.WIP1 enhances tumor formation in a sonic hedgehog-dependent model of medulloblastoma.Association between overexpression of Wip1 and prognosis of patients with non-small cell lung cancer Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint Molecular predictors of human nervous system cancer responsiveness to enediyne chemotherapy.REST is a novel prognostic factor and therapeutic target for medulloblastoma Genetic variants and mutations of PPM1D control the response to DNA damage.The rationale for targeted therapies in medulloblastoma.Medulloblastomics: the end of the beginning.Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication.Checkpoint control and cancer.Crosstalk between the DNA damage response pathway and microRNAs.Wip1 phosphatase in breast cancer.p53 and Meduloblastoma.Wip1 regulates SKOV3 cell apoptosis through the p38 MAPK signaling pathway.Chemical Inhibition of Wild-Type p53-Induced Phosphatase 1 (WIP1/PPM1D) by GSK2830371 Potentiates the Sensitivity to MDM2 Inhibitors in a p53-Dependent Manner.Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma.PPM1D exerts its oncogenic properties in human pancreatic cancer through multiple mechanisms.

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P2860

Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

http://www.wikidata.org/entity/Q36326949

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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name

Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

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Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

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type

label

Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

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Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

@en

prefLabel

Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

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Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

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S11060-007-9470-8

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Journal of Neuro-Oncology

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Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

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P2093

John Y H Kim

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Lawrence A Donehower

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Mark A Shepard

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Massimiliano De Bortoli

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Pulivarthi H Rao

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Robert C Castellino

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Sung-Hwan Moon

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Xiongbin Lu

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P2860

Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

The HBP1 transcriptional repressor participates in RAS-induced premature senescence

Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virus

WAF1, a potential mediator of p53 tumor suppression

Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

p53 mutations in nonastrocytic human brain tumors

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