Rapamycin activates autophagy and improves myelination in explant cultures from neuropathic mice. - Wikidata - wikimedia - TriplyDB

Rapamycin activates autophagy and improves myelination in explant cultures from neuropathic mice.

Rapamycin activates autophagy and improves myelination in explant cultures from neuropathic mice.

http://www.wikidata.org/entity/Q36338250

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A brief review of recent Charcot-Marie-Tooth research and priorities Molecular regulators of nerve conduction - Lessons from inherited neuropathies and rodent genetic models Collaboration for rare disease drug discovery research Therapeutic potential of HSP90 inhibition for neurofibromatosis type 2.Hyperbaric oxygen treatment attenuates neuropathic pain by elevating autophagy flux via inhibiting mTOR pathway.Autophagy promotes oligodendrocyte survival and function following dysmyelination in a long-lived myelin mutant Rapamycin promotes Schwann cell migration and nerve growth factor secretion.Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection.The PMP22 gene and its related diseases.PMP22 is critical for actin-mediated cellular functions and for establishing lipid rafts.mTOR kinase: a possible pharmacological target in the management of chronic pain.Mutations associated with Charcot-Marie-Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways.Male-Specific Alleviation of Iron-Induced Striatal Injury by Inhibition of Autophagy Expression pattern and functions of autophagy-related gene atg5 in zebrafish organogenesis.Protein misfolding and clearance in demyelinating peripheral neuropathies: Therapeutic implications.Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves.Rapamycin improves peripheral nerve myelination while it fails to benefit neuromuscular performance in neuropathic mice.The palmitoylation state of PMP22 modulates epithelial cell morphology and migration Glycyrrhetinic acid induces cytoprotective autophagy via the inositol-requiring enzyme 1α-c-Jun N-terminal kinase cascade in non-small cell lung cancer cells.Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice Liposomes to target peripheral neurons and Schwann cells.Autophagy and cathepsin L are involved in the antinociceptive effect of DMBC in a mouse acetic acid-writhing model Murine therapeutic models for Charcot-Marie-Tooth (CMT) disease.mTOR kinase, a key player in the regulation of glial functions: relevance for the therapy of multiple sclerosis.Dietary restriction supports peripheral nerve health by enhancing endogenous protein quality control mechanisms Axonal regulation of Schwann cell ensheathment and myelination.Therapeutic options in Charcot-Marie-Tooth diseases.Role of autophagy in the pathogenesis of multiple sclerosis.Promoting peripheral myelin repair.The repair Schwann cell and its function in regenerating nerves.Autophagy as an Emerging Common Pathomechanism in Inherited Peripheral Neuropathies.PI3K-Akt-mTOR axis sustains rotavirus infection via the 4E-BP1 mediated autophagy pathway and represents an antiviral target.Arrest of myelination and reduced axon growth when Schwann cells lack mTOR.Autophagy activator promotes neuronal differentiation of adult adipose-derived stromal cells.Autophagy aids membrane expansion by neuropathic Schwann cells.Blocking autophagy enhances the apoptotic effect of 18β-glycyrrhetinic acid on human sarcoma cells via endoplasmic reticulum stress and JNK activation.Therapeutic implications of protein homeostasis in demyelinating peripheral neuropathies.The involvement of autophagy pathway in exaggerated ischemic brain damage in diabetic mice.Autophagy reduces neuronal damage and promotes locomotor recovery via inhibition of apoptosis after spinal cord injury in rats.Modeling the Pathogenesis of Charcot-Marie-Tooth Disease Type 1A Using Patient-Specific iPSCs.

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Rapamycin activates autophagy and improves myelination in explant cultures from neuropathic mice.

http://www.wikidata.org/entity/Q36338250

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2010 nî lūn-bûn

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2010年学术文章

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2010年學術文章

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2010年學術文章

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2010年學術文章

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Rapamycin activates autophagy ...... ultures from neuropathic mice.

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Rapamycin activates autophagy ...... ultures from neuropathic mice.

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Rapamycin activates autophagy ...... ultures from neuropathic mice.

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Rapamycin activates autophagy ...... ultures from neuropathic mice.

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Rapamycin activates autophagy ...... ultures from neuropathic mice.

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Jessica Nicks

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Jonathan D Verrier

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Lucia Notterpek

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Sunitha Rangaraju

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William A Dunn

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P2860

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments.

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

The autophagy machinery is required to initiate hepatitis C virus replication

Diagnosis, natural history, and management of Charcot–Marie–Tooth disease

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell myelination

How to interpret LC3 immunoblotting

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