Arrest of myelination and reduced axon growth when Schwann cells lack mTOR. - Wikidata - wikimedia - TriplyDB

Arrest of myelination and reduced axon growth when Schwann cells lack mTOR.

Arrest of myelination and reduced axon growth when Schwann cells lack mTOR.

http://www.wikidata.org/entity/Q41880723

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Kif13b Regulates PNS and CNS Myelination through the Dlg1 Scaffold New insights on Schwann cell development Elevated protein carbonylation, and misfolding in sciatic nerve from db/db and Sod1(-/-) mice: plausible link between oxidative stress and demyelination Autophagy is involved in the reduction of myelinating Schwann cell cytoplasm during myelin maturation of the peripheral nerve Nudging oligodendrocyte intrinsic signaling to remyelinate and repair: Estrogen receptor ligand effects.Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance.A mutation in the canine gene encoding folliculin-interacting protein 2 (FNIP2) associated with a unique disruption in spinal cord myelination.mTORC1 is essential for early steps during Schwann cell differentiation of amniotic fluid stem cells and regulates lipogenic gene expression Loss of glial neurofascin155 delays developmental synapse elimination at the neuromuscular junction FAK is required for Schwann cell spreading on immature basal lamina to coordinate the radial sorting of peripheral axons with myelination mTOR kinase: a possible pharmacological target in the management of chronic pain.Neurofascin 140 is an embryonic neuronal neurofascin isoform that promotes the assembly of the node of Ranvier Phosphorylation of LKB1/Par-4 establishes Schwann cell polarity to initiate and control myelin extent The thrombin receptor is a critical extracellular switch controlling myelination.Rapamycin improves peripheral nerve myelination while it fails to benefit neuromuscular performance in neuropathic mice.Expression of oncogenic BRAFV600E in melanocytes induces Schwannian differentiation in vivo.Age-related morphological regression of myelinated fibers and capillary architecture of distal peripheral nerves in rats.Interplay between exercise and dietary fat modulates myelinogenesis in the central nervous system.mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.The CMT4B disease-causing phosphatases Mtmr2 and Mtmr13 localize to the Schwann cell cytoplasm and endomembrane compartments, where they depend upon each other to achieve wild-type levels of protein expression.Akt Regulates Axon Wrapping and Myelin Sheath Thickness in the PNS Sustained activation of ERK1/2 MAPK in oligodendrocytes and schwann cells enhances myelin growth and stimulates oligodendrocyte progenitor expansion.Cholesterol Biosynthesis Supports Myelin Gene Expression and Axon Ensheathment through Modulation of P13K/Akt/mTor Signaling.Signals regulating myelination in peripheral nerves and the Schwann cell response to injury.A critical review of mTOR inhibitors and epilepsy: from basic science to clinical trials.YAP/TAZ initiate and maintain Schwann cell myelination.Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination.Conditional ablation of raptor or rictor has differential impact on oligodendrocyte differentiation and CNS myelination.Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system.Differential stability of PNS and CNS nodal complexes when neuronal neurofascin is lost.DDIT4/REDD1/RTP801 is a novel negative regulator of Schwann cell myelination.Akt/mTOR signalling in myelination.mTOR inhibition in epilepsy: rationale and clinical perspectives.Molecular signaling mechanisms of axon-glia communication in the peripheral nervous system.Schwann cell myelination mTOR in Brain Physiology and Pathologies.mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells.Assembly of CNS Nodes of Ranvier in Myelinated Nerves Is Promoted by the Axon Cytoskeleton.Inhibition of the mTOR pathway in abdominal aortic aneurysm: implications of smooth muscle cell contractile phenotype, inflammation, and aneurysm expansion.Molecular Mechanisms Involved in Schwann Cell Plasticity

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P2860

Arrest of myelination and reduced axon growth when Schwann cells lack mTOR.

http://www.wikidata.org/entity/Q41880723

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

@zh-cn

name

Arrest of myelination and reduced axon growth when Schwann cells lack mTOR.

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type

label

Arrest of myelination and reduced axon growth when Schwann cells lack mTOR.

@en

prefLabel

Arrest of myelination and reduced axon growth when Schwann cells lack mTOR.

@en

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JNEUROSCI.4814-11.2012

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Journal of Neuroscience

P1476

Arrest of myelination and reduced axon growth when Schwann cells lack mTOR.

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P2093

Diane L Sherman

http://www.w3.org/2001/XMLSchema#string

Lai-Man N Wu

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Matthew Grove

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Michiel Krols

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Peter J Brophy

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P2860

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

An emerging role for TOR signaling in mammalian tissue and stem cell physiology

mTOR: from growth signal integration to cancer, diabetes and ageing

TOR signaling in growth and metabolism

Severe neuropathies in mice with targeted mutations in the ErbB3 receptor

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

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1817-1825

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10.1523/JNEUROSCI.4814-11.2012

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5

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22302821

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