De-immunization of therapeutic proteins by T-cell epitope modification.
about
Application of IgG-derived natural Treg epitopes (IgG Tregitopes) to antigen-specific tolerance induction in a murine model of type 1 diabetesBeyond humanization and de-immunization: tolerization as a method for reducing the immunogenicity of biologicsStructure-guided deimmunization of therapeutic proteinsMapping the Pareto optimal design space for a functionally deimmunized biotherapeutic candidateComputationally driven deletion of broadly distributed T cell epitopes in a biotherapeutic candidate.Immunogenicity of mAbs in non-human primates during nonclinical safety assessmentCoupling sensitive in vitro and in silico techniques to assess cross-reactive CD4(+) T cells against the swine-origin H1N1 influenza virus.Optimization algorithms for functional deimmunization of therapeutic proteins.High throughput T epitope mapping and vaccine developmentEffect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo.EpiSweep: Computationally Driven Reengineering of Therapeutic Proteins to Reduce Immunogenicity While Maintaining Function.Design and analysis of immune-evading enzymes for ADEPT therapy.Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A.An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes.A high throughput MHC II binding assay for quantitative analysis of peptide epitopes.Dana-Farber repository for machine learning in immunology.Structure-based redesign of proteins for minimal T-cell epitope contentA divide-and-conquer approach to determine the Pareto frontier for optimization of protein engineering experimentsPopulation-specific design of de-immunized protein biotherapeutics.Addressing the Immunogenicity of the Cargo and of the Targeting Antibodies with a Focus on Demmunized Bacterial Toxins and on Antibody-Targeted Human Effector Proteins.
P2860
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P2860
De-immunization of therapeutic proteins by T-cell epitope modification.
description
2005 nî lūn-bûn
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2005年の論文
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
@zh-sg
2005年學術文章
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2005年學術文章
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2005年學術文章
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name
De-immunization of therapeutic proteins by T-cell epitope modification.
@ast
De-immunization of therapeutic proteins by T-cell epitope modification.
@en
type
label
De-immunization of therapeutic proteins by T-cell epitope modification.
@ast
De-immunization of therapeutic proteins by T-cell epitope modification.
@en
prefLabel
De-immunization of therapeutic proteins by T-cell epitope modification.
@ast
De-immunization of therapeutic proteins by T-cell epitope modification.
@en
P2093
P1476
De-immunization of therapeutic proteins by T-cell epitope modification
@en
P2093
P304
P577
2005-01-01T00:00:00Z